Research output per year
Research output per year
Personal profile
Research interests
- The role of endogenous estradiol metabolites in preeclamsia, ischemia reperfusion injury and Alzheimer’s disease. (Gender differences in diseases). The projects aim at understanding how estradiol metabolites offer protection in these diseases/conditions thus leading to new therapeutic avenues. Currently the role of estradiol metabolites in Alzheimer’s disease is actively being investigated
- Investigating dietary supplements/natural compounds as inhibitors of nicotine metabolizing enzyme P450 2A6 as a means of reducing smoking by inhibiting nicotine metabolism. (Currently active).
- Peritoneal adhesions, cause and methods of resolving them. The project aims at identifying mechanisms and therapeutic methods for resolving adhesions, a post-operative problem resulting in pain and usually requiring second surgical operation. Adhesions result when tissues adhere together after surgery as a result of injury.
- The role of MIF-Glucocorticoid axis in the pathogenesis atherosclerosis and other inflammatory cardiovascular diseases. The project aims at understanding how inflammation can be resolved in these chronic inflammatory conditions by modulating endogenous regulatory switches such as MIF-glucocordicoids, thus leading to inflammation resolution and therapy. Special interest also for inflammation in cancer.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Master, University of Pittsburgh
2005 → 2007
PhD, University of Pittsburgh
1998 → 2002
Bachelor, Denison University
1995 → 1998
External positions
Collaborating Researcher, Center for Research and Technology-Thessaly
2012 → 2014
Head of R&D, Vethellas SA
2010 → 2013
Managing Director, Biomedcode Hellas SA
2007 → 2010
Research Instructor, University of Pittsburgh
2002 → 2007
Fingerprint
Dive into the research topics where Lefteris Zacharia is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Application of artificial intelligence in pharmaceutical development
Mourelatou, E. A., Iosif, E., Galatou, E., Sarigiannis, Y., Vlasiou, M. C., Zacharia, L. & Petrou, C. C., 1 Jan 2024, Novel Formulations and Future Trends: Recent and Future Trends in Pharmaceutics, Volume 3. Elsevier, Vol. 3. p. 415-451 37 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
-
Editorial: Targeting mitochondrial dysfunction for the diagnosis and treatment of Alzheimer’s and cognitive-related diseases
Vlasiou, M. C., Zacharia, L. C., Douni, E. & Papaneophytou, C., 2024, In: Frontiers in Pharmacology. 15, 1455646.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Pharmacodynamic characteristics, safety profile, and interactions of CDK4/6 inhibitors (CDK4/6i) in HR1/HER2– advanced/metastatic breast cancer
Savvidou, A., Kitiri, S., Zacharia, L., Constantinidou, A. & Petrou, C. C., 5 Jul 2024, In: European Journal of Oncology Pharmacy. 7, 2, e54.Research output: Contribution to journal › Review article › peer-review
Open Access -
Role of Bioactives in Neurodegenerative Diseases
Zacharia, L. C., May 2024, In: International Journal of Molecular Sciences. 25, 9, 4951.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Systematic Review of Naturally Derived Substances That Act as Inhibitors of the Nicotine Metabolizing Enzyme Cytochrome P450 2A6
Tzoupis, H., Papavasileiou, K. D., Papatzelos, S., Mavrogiorgis, A., Zacharia, L. C., Melagraki, G. & Afantitis, A., Aug 2024, In: International Journal of Molecular Sciences. 25, 15, 8031.Research output: Contribution to journal › Review article › peer-review
Open Access