Research Output per year
Personal profile
Research interests
- The role of endogenous estradiol metabolites in preeclamsia, ischemia reperfusion injury and Alzheimer’s disease. (Gender differences in diseases). The projects aim at understanding how estradiol metabolites offer protection in these diseases/conditions thus leading to new therapeutic avenues. Currently the role of estradiol metabolites in Alzheimer’s disease is actively being investigated
- Investigating dietary supplements/natural compounds as inhibitors of nicotine metabolizing enzyme P450 2A6 as a means of reducing smoking by inhibiting nicotine metabolism. (Currently active).
- Peritoneal adhesions, cause and methods of resolving them. The project aims at identifying mechanisms and therapeutic methods for resolving adhesions, a post-operative problem resulting in pain and usually requiring second surgical operation. Adhesions result when tissues adhere together after surgery as a result of injury.
- The role of MIF-Glucocorticoid axis in the pathogenesis atherosclerosis and other inflammatory cardiovascular diseases. The project aims at understanding how inflammation can be resolved in these chronic inflammatory conditions by modulating endogenous regulatory switches such as MIF-glucocordicoids, thus leading to inflammation resolution and therapy. Special interest also for inflammation in cancer.
Education/Academic qualification
Master, University of Pittsburgh
2005 → 2007
PhD, University of Pittsburgh
1998 → 2002
Bachelor, Denison University
1995 → 1998
External positions
Collaborating Researcher, Center for Research and Technology-Thessaly
2012 → 2014Head of R&D, Vethellas SA
2010 → 2013Managing Director, Biomedcode Hellas SA
2007 → 2010Research Instructor, University of Pittsburgh
2002 → 2007Fingerprint Dive into the research topics where Lefteris Zacharia is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
Estradiol
Medicine & Life Sciences
Adenosine
Medicine & Life Sciences
Smooth Muscle Myocytes
Medicine & Life Sciences
Catechol O-Methyltransferase
Medicine & Life Sciences
Vascular Smooth Muscle
Medicine & Life Sciences
Purinergic P1 Receptors
Medicine & Life Sciences
Catecholamines
Medicine & Life Sciences
Estrogen Receptors
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 2000 2019
Cheminformatics and virtual screening studies of COMT inhibitors as potential Parkinson’s disease therapeutics
Moschovou, K., Melagraki, G., Mavromoustakos, T., Zacharia, L. C. & Afantitis, A., 1 Jan 2019, (Accepted/In press) In : Expert Opinion on Drug Discovery.Research output: Contribution to journal › Review article
Parkinson Disease
Dopamine
Computer Simulation
Secondary Parkinson Disease
Therapeutics
Collagen content and extracellular matrix cause cytoskeletal remodelling in pancreatic fibroblasts
Stylianou, A., Gkretsi, V., Louca, M., Zacharia, L. C. & Stylianopoulos, T., 1 Jan 2019, In : Journal of the Royal Society Interface. 16, 154, 0226.Research output: Contribution to journal › Article
Fibroblasts
Collagen
Extracellular Matrix
Stress Fibers
Cytoskeleton
Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform
Gkretsi, V., Kalli, M., Efstathiades, C., Papageorgis, P., Papanikolaou, V., Zacharia, L. C., Tsezou, A., Athanassiou, E. & Stylianopoulos, T., 1 Dec 2019, In : Scientific Reports. 9, 1, 10050.Research output: Contribution to journal › Article
Open Access
Protein Isoforms
Up-Regulation
Breast Neoplasms
Extracellular Matrix Proteins
MCF-7 Cells
On the issue of the derivation of permitted daily exposure for the androgen receptor antagonist flutamide
Zacharia, L. C., 1 Jun 2018, In : Toxicological Sciences. 163, 2, p. 334 1 p.Research output: Contribution to journal › Letter
1
Citation
(Scopus)
Permitted daily exposure of the androgen receptor antagonist flutamide
Zacharia, L. C., 1 Oct 2017, In : Toxicological Sciences. 159, 2, p. 279-289 11 p.Research output: Contribution to journal › Article
Androgen Receptor Antagonists
Flutamide
Toxicity
No-Observed-Adverse-Effect Level
Androgen Receptors