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Personal profile

Research interests

  1. The role of endogenous estradiol metabolites in preeclamsia, ischemia reperfusion injury and Alzheimer’s disease. (Gender differences in diseases). The projects aim at understanding how estradiol metabolites offer protection in these diseases/conditions thus leading to new therapeutic avenues. Currently the role of estradiol metabolites in Alzheimer’s disease is actively being investigated
  2. Investigating dietary supplements/natural compounds as inhibitors of nicotine metabolizing enzyme P450 2A6 as a means of reducing smoking by inhibiting nicotine metabolism. (Currently active).
  3. Peritoneal adhesions, cause and methods of resolving them. The project aims at identifying mechanisms and therapeutic methods for resolving adhesions, a post-operative problem resulting in pain and usually requiring second surgical operation. Adhesions result when tissues adhere together after surgery as a result of injury.
  4. The role of MIF-Glucocorticoid axis in the pathogenesis atherosclerosis and other inflammatory cardiovascular diseases. The project aims at understanding how inflammation can be resolved in these chronic inflammatory conditions by modulating endogenous regulatory switches such as MIF-glucocordicoids, thus leading to inflammation resolution and therapy. Special interest also for inflammation in cancer.

Education/Academic qualification

Master, University of Pittsburgh


PhD, University of Pittsburgh


Bachelor, Denison University


External positions

Collaborating Researcher, Center for Research and Technology-Thessaly


Head of R&D, Vethellas SA


Managing Director, Biomedcode Hellas SA


Research Instructor, University of Pittsburgh


Fingerprint Dive into the research topics where Lefteris Zacharia is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Estradiol Medicine & Life Sciences
Adenosine Medicine & Life Sciences
Smooth Muscle Myocytes Medicine & Life Sciences
Catechol O-Methyltransferase Medicine & Life Sciences
Vascular Smooth Muscle Medicine & Life Sciences
Purinergic P1 Receptors Medicine & Life Sciences
Catecholamines Medicine & Life Sciences
Estrogen Receptors Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2000 2019

Cheminformatics and virtual screening studies of COMT inhibitors as potential Parkinson’s disease therapeutics

Moschovou, K., Melagraki, G., Mavromoustakos, T., Zacharia, L. C. & Afantitis, A., 1 Jan 2019, (Accepted/In press) In : Expert Opinion on Drug Discovery.

Research output: Contribution to journalReview article

Parkinson Disease
Computer Simulation
Secondary Parkinson Disease
1 Citation (Scopus)

Collagen content and extracellular matrix cause cytoskeletal remodelling in pancreatic fibroblasts

Stylianou, A., Gkretsi, V., Louca, M., Zacharia, L. C. & Stylianopoulos, T., 1 Jan 2019, In : Journal of the Royal Society Interface. 16, 154, 0226.

Research output: Contribution to journalArticle

Extracellular Matrix
Stress Fibers

Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform

Gkretsi, V., Kalli, M., Efstathiades, C., Papageorgis, P., Papanikolaou, V., Zacharia, L. C., Tsezou, A., Athanassiou, E. & Stylianopoulos, T., 1 Dec 2019, In : Scientific Reports. 9, 1, 10050.

Research output: Contribution to journalArticle

Open Access
Protein Isoforms
Breast Neoplasms
Extracellular Matrix Proteins
MCF-7 Cells
2 Citations (Scopus)

Permitted daily exposure of the androgen receptor antagonist flutamide

Zacharia, L. C., 1 Oct 2017, In : Toxicological Sciences. 159, 2, p. 279-289 11 p.

Research output: Contribution to journalArticle

Androgen Receptor Antagonists
No-Observed-Adverse-Effect Level
Androgen Receptors