Personal profile
Research interests
- The role of endogenous estradiol metabolites in preeclamsia, ischemia reperfusion injury and Alzheimer’s disease. (Gender differences in diseases). The projects aim at understanding how estradiol metabolites offer protection in these diseases/conditions thus leading to new therapeutic avenues. Currently the role of estradiol metabolites in Alzheimer’s disease is actively being investigated
- Investigating dietary supplements/natural compounds as inhibitors of nicotine metabolizing enzyme P450 2A6 as a means of reducing smoking by inhibiting nicotine metabolism. (Currently active).
- Peritoneal adhesions, cause and methods of resolving them. The project aims at identifying mechanisms and therapeutic methods for resolving adhesions, a post-operative problem resulting in pain and usually requiring second surgical operation. Adhesions result when tissues adhere together after surgery as a result of injury.
- The role of MIF-Glucocorticoid axis in the pathogenesis atherosclerosis and other inflammatory cardiovascular diseases. The project aims at understanding how inflammation can be resolved in these chronic inflammatory conditions by modulating endogenous regulatory switches such as MIF-glucocordicoids, thus leading to inflammation resolution and therapy. Special interest also for inflammation in cancer.
Education/Academic qualification
Master, University of Pittsburgh
2005 → 2007
PhD, University of Pittsburgh
1998 → 2002
Bachelor, Denison University
1995 → 1998
External positions
Collaborating Researcher, Center for Research and Technology-Thessaly
2012 → 2014
Head of R&D, Vethellas SA
2010 → 2013
Managing Director, Biomedcode Hellas SA
2007 → 2010
Research Instructor, University of Pittsburgh
2002 → 2007
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Cognitive impairment in CKD patients: a guidance document by the CONNECT network
CONNECT Action (Cognitive Decline in Nephro-Neurology European Cooperative Target) collaborators, 1 Feb 2025, In: Clinical Kidney Journal. 18, 2, sfae294.Research output: Contribution to journal › Review article › peer-review
Open Access -
Deciphering the Role of Adrenergic Receptors in Alzheimer’s Disease: Paving the Way for Innovative Therapies
Miliotou, A. N., Kotsoni, A. & Zacharia, L. C., Jan 2025, In: Biomolecules. 15, 1, 128.Research output: Contribution to journal › Review article › peer-review
Open Access -
Efficacy and safety of vaginal suppositories containing combination of Natamycin and Lactulose in treatment of vulvovaginal candidiasis: international, randomized, controlled, superiority clinical trial (combination of Natamycin and Lactulose for treatment of vulvovaginal candidiasis)
Volkova, O. N., Amel’chenko, E. V., Makeeva, O. V., Tolmachev, S. A., Lesovaya, E. A., Zacharia, L. C. & Dikovskiy, A. V., Dec 2025, In: BMC Women's Health. 25, 1, 77.Research output: Contribution to journal › Article › peer-review
Open Access -
In vitro models: Can they unravel the complexities of cancer cell metastasis?
Pafitanis, S., Zacharia, L. C., Stylianou, A. & Gkretsi, V., Apr 2025, In: Biochimica et Biophysica Acta - Reviews on Cancer. 1880, 2, 189293.Research output: Contribution to journal › Review article › peer-review
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Animal models to study cognitive impairment of chronic kidney disease
CONNECT Consortium, Jun 2024, In: American Journal of Physiology - Renal Physiology. 326, 6, p. F894-F916Research output: Contribution to journal › Review article › peer-review