Effect of probiotics on cognitive functioning of patients with early Alzheimer's Disease

Our main objective in this project is to investigate whether administration of probiotics to patients with mild AD reduces neuroinflammation, improves cognitive functioning and modifies neurophysiological measures, compared to a patient group that receives placebo (no active probiotics). We hypothesize that, following probiotic administration, we will see a reduction in specific blood inflammatory markers, which will correlate with positive changes in neurophysiological activity and cognitive test scores, in the probiotics but not the placebo group. We will also study the microbiome composition of the participants to identify whether positive changes are related to specific microbiome profiles.

The project is funded by the Alzheimer's Association.