Abstract
Feline infectious peritonitis (FIP) is a severe and invariably fatal disease affecting both domestic and wild felines with limited effective therapeutic options available. By considering the significant immunomodulatory effects of vitamin E observed in both animal and human models under physiological and pathological conditions, we have provided a full in silico investigation of vitamin E and related compounds and their effect on the crystal structure of feline infectious peritonitis virus 3C-like protease (FIPV-3CLpro). This work revealed the β-tocotrienol and δ-tocotrienol analogs as inhibitor candidates for this protein, suggesting their potential as possible drug compounds against FIP or their supplementary use with current medicines against this disease.
Original language | English |
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Article number | 424 |
Journal | Veterinary Sciences |
Volume | 11 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sept 2024 |
Keywords
- drug discovery
- FIP
- inhibitors
- vitamin E