β-Tocotrienol and δ-Tocotrienol as Additional Inhibitors of the Main Protease of Feline Infectious Peritonitis Virus: An In Silico Analysis

Manos C. Vlasiou, Georgios Nikolaou, Kyriakos Spanoudes, Daphne E. Mavrides

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Feline infectious peritonitis (FIP) is a severe and invariably fatal disease affecting both domestic and wild felines with limited effective therapeutic options available. By considering the significant immunomodulatory effects of vitamin E observed in both animal and human models under physiological and pathological conditions, we have provided a full in silico investigation of vitamin E and related compounds and their effect on the crystal structure of feline infectious peritonitis virus 3C-like protease (FIPV-3CLpro). This work revealed the β-tocotrienol and δ-tocotrienol analogs as inhibitor candidates for this protein, suggesting their potential as possible drug compounds against FIP or their supplementary use with current medicines against this disease.

    Original languageEnglish
    Article number424
    JournalVeterinary Sciences
    Volume11
    Issue number9
    DOIs
    Publication statusPublished - Sept 2024

    Keywords

    • drug discovery
    • FIP
    • inhibitors
    • vitamin E

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