2006 to 2019 Story; percutaneously implantable aortic valve prototypes

Constantinos Zervides, Ornella Nohra, Gabriel Hunduma, Neil Wild Thomas, Ramy Samia

Research output: Contribution to journalReview articlepeer-review


Aims: A review was conducted on the composition, advantages and limitations of available aortic valve prototypes to create an ideal valve for percutaneous implantation. Patients Patients with multiple comorbidities who cannot withstand the risks of open cardiac surgery. Methodology: The search was performed using online databases and textbooks. Articles were excluded based on specific criterion. Results: Ten prototypes created between 2006 and 2019 were found and reviewed. The prototypes had a set of advantages and limitations with their characteristics coinciding at times. Conclusions: The ideal percutaneously implantable aortic valve should have minimum coaptation height, zero folds in the leaflets, minimum valve height, minimum leaflet flexion and three leaflets. It can be composed of biological or synthetic material, as long as it provides minimal risk of thrombosis. However, more studies are needed to ensure other ideal parameters.

Original languageEnglish
Article number223
JournalJournal of Cardiothoracic Surgery
Issue number1
Publication statusPublished - Dec 2021
Externally publishedYes


  • Aortic valve
  • Cardiovascular implant
  • Percutaneous implantation
  • Prototype(s)


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