A double blind, placebo-controlled study to assess the effect of famciclovir on virus replication in patients with chronic hepatitis B virus infection

J. Main; J. L. Brown; C. Howells; R. Galassini; M. Crossey; P. Karayiannis; P. Georgiou; G. Atkinson; H. C. Thomas

A double blind, placebo-controlled study to assess the effect of famciclovir on virus replication in patients with chronic hepatitis B virus infection

J. Main
, J. L. Brown
, C. Howells
, R. Galassini
, M. Crossey
, P. Karayiannis
, P. Georgiou
, G. Atkinson
, H. C. Thomas

Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

This is the first double-blind controlled study of famciclovir, an oral antiviral agent, as potential therapy for chronic hepatitis B virus (HBV) carriers. A fall of more than 90% in HBV DNA levels was noted in six of 11 evaluable patients treated with a 10 day course of oral famciclovir. Further studies with more prolonged therapy are ongoing.

Original language	English
Pages (from-to)	211-215
Number of pages	5
Journal	Journal of Viral Hepatitis
Volume	3
Issue number	4
Publication status	Published - Jul 1996

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Famciclovir
Hepatitis B virus
Nucleoside analogue

Cite this

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title = "A double blind, placebo-controlled study to assess the effect of famciclovir on virus replication in patients with chronic hepatitis B virus infection",

abstract = "This is the first double-blind controlled study of famciclovir, an oral antiviral agent, as potential therapy for chronic hepatitis B virus (HBV) carriers. A fall of more than 90\% in HBV DNA levels was noted in six of 11 evaluable patients treated with a 10 day course of oral famciclovir. Further studies with more prolonged therapy are ongoing.",

keywords = "Famciclovir, Hepatitis B virus, Nucleoside analogue",

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year = "1996",

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T1 - A double blind, placebo-controlled study to assess the effect of famciclovir on virus replication in patients with chronic hepatitis B virus infection

AU - Main, J.

AU - Brown, J. L.

AU - Howells, C.

AU - Galassini, R.

AU - Crossey, M.

AU - Karayiannis, P.

AU - Georgiou, P.

AU - Atkinson, G.

AU - Thomas, H. C.

PY - 1996/7

Y1 - 1996/7

N2 - This is the first double-blind controlled study of famciclovir, an oral antiviral agent, as potential therapy for chronic hepatitis B virus (HBV) carriers. A fall of more than 90% in HBV DNA levels was noted in six of 11 evaluable patients treated with a 10 day course of oral famciclovir. Further studies with more prolonged therapy are ongoing.

AB - This is the first double-blind controlled study of famciclovir, an oral antiviral agent, as potential therapy for chronic hepatitis B virus (HBV) carriers. A fall of more than 90% in HBV DNA levels was noted in six of 11 evaluable patients treated with a 10 day course of oral famciclovir. Further studies with more prolonged therapy are ongoing.

KW - Famciclovir

KW - Hepatitis B virus

KW - Nucleoside analogue

UR - https://www.scopus.com/pages/publications/0030179646

M3 - Article

C2 - 8871884

AN - SCOPUS:0030179646

SN - 1352-0504

VL - 3

SP - 211

EP - 215

JO - Journal of Viral Hepatitis

JF - Journal of Viral Hepatitis

IS - 4

ER -

A double blind, placebo-controlled study to assess the effect of famciclovir on virus replication in patients with chronic hepatitis B virus infection

Abstract

UN SDGs

Keywords

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