A schematic workflow for collecting information about the interaction between copy number variants and MicroRNAs using existing resources

Harsh Dweep, Norbert Gretz, Kyriakos Felekkis

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) and copy number variations (CNVs) are two extensively studied genomic components in the field of modern biology - as they have been found to be associated with many disorders such as cancer, Alzheimer, pancreatitis, HIV susceptibility, beta-thalassemia, and glomerulonephritis. Several studies suggested that an alteration in CNV-miRNA interaction could result in some human diseases such as cancer. Therefore, the possible miRNA-binding site information within the CNV genes opens new avenues in understanding such disorders. In this chapter, we present a schematic approach for collecting the information on CNV-miRNA interactions using miRWalk and TargetScan databases.

Original languageEnglish
Title of host publicationRNA Mapping
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Pages307-320
Number of pages14
Volume1182
ISBN (Print)9781493910618
DOIs
Publication statusPublished - 2014

Publication series

NameMethods in Molecular Biology
Volume1182
ISSN (Print)1064-3745

Keywords

  • 3'-UTR
  • CNV-miRNA interaction predictions
  • Copy number variant
  • MicroRNA
  • miRWalk

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