A schematic workflow for collecting information about the interaction between copy number variants and MicroRNAs using existing resources

Harsh Dweep; Norbert Gretz; Kyriakos Felekkis

doi:10.1007/978-1-4939-1062-5_26

A schematic workflow for collecting information about the interaction between copy number variants and MicroRNAs using existing resources

Harsh Dweep, Norbert Gretz, Kyriakos Felekkis

School of Life and Health Sciences

Heidelberg University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

MicroRNAs (miRNAs) and copy number variations (CNVs) are two extensively studied genomic components in the field of modern biology - as they have been found to be associated with many disorders such as cancer, Alzheimer, pancreatitis, HIV susceptibility, beta-thalassemia, and glomerulonephritis. Several studies suggested that an alteration in CNV-miRNA interaction could result in some human diseases such as cancer. Therefore, the possible miRNA-binding site information within the CNV genes opens new avenues in understanding such disorders. In this chapter, we present a schematic approach for collecting the information on CNV-miRNA interactions using miRWalk and TargetScan databases.

Original language	English
Title of host publication	RNA Mapping
Subtitle of host publication	Methods and Protocols
Publisher	Humana Press Inc.
Pages	307-320
Number of pages	14
Volume	1182
ISBN (Print)	9781493910618
DOIs	https://doi.org/10.1007/978-1-4939-1062-5_26
Publication status	Published - 2014

Publication series

Name	Methods in Molecular Biology
Volume	1182
ISSN (Print)	1064-3745

Keywords

3'-UTR
CNV-miRNA interaction predictions
Copy number variant
MicroRNA
miRWalk

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-1-4939-1062-5_26

Cite this

@inbook{1f54ec25d43d4552af1490007596860f,

title = "A schematic workflow for collecting information about the interaction between copy number variants and MicroRNAs using existing resources",

abstract = "MicroRNAs (miRNAs) and copy number variations (CNVs) are two extensively studied genomic components in the field of modern biology - as they have been found to be associated with many disorders such as cancer, Alzheimer, pancreatitis, HIV susceptibility, beta-thalassemia, and glomerulonephritis. Several studies suggested that an alteration in CNV-miRNA interaction could result in some human diseases such as cancer. Therefore, the possible miRNA-binding site information within the CNV genes opens new avenues in understanding such disorders. In this chapter, we present a schematic approach for collecting the information on CNV-miRNA interactions using miRWalk and TargetScan databases.",

keywords = "3'-UTR, CNV-miRNA interaction predictions, Copy number variant, MicroRNA, miRWalk",

author = "Harsh Dweep and Norbert Gretz and Kyriakos Felekkis",

year = "2014",

doi = "10.1007/978-1-4939-1062-5_26",

language = "English",

isbn = "9781493910618",

volume = "1182",

series = "Methods in Molecular Biology",

publisher = "Humana Press Inc.",

pages = "307--320",

booktitle = "RNA Mapping",

}

A schematic workflow for collecting information about the interaction between copy number variants and MicroRNAs using existing resources. / Dweep, Harsh; Gretz, Norbert; Felekkis, Kyriakos.
RNA Mapping: Methods and Protocols. Vol. 1182 Humana Press Inc., 2014. p. 307-320 (Methods in Molecular Biology; Vol. 1182).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - A schematic workflow for collecting information about the interaction between copy number variants and MicroRNAs using existing resources

AU - Dweep, Harsh

AU - Gretz, Norbert

AU - Felekkis, Kyriakos

PY - 2014

Y1 - 2014

N2 - MicroRNAs (miRNAs) and copy number variations (CNVs) are two extensively studied genomic components in the field of modern biology - as they have been found to be associated with many disorders such as cancer, Alzheimer, pancreatitis, HIV susceptibility, beta-thalassemia, and glomerulonephritis. Several studies suggested that an alteration in CNV-miRNA interaction could result in some human diseases such as cancer. Therefore, the possible miRNA-binding site information within the CNV genes opens new avenues in understanding such disorders. In this chapter, we present a schematic approach for collecting the information on CNV-miRNA interactions using miRWalk and TargetScan databases.

AB - MicroRNAs (miRNAs) and copy number variations (CNVs) are two extensively studied genomic components in the field of modern biology - as they have been found to be associated with many disorders such as cancer, Alzheimer, pancreatitis, HIV susceptibility, beta-thalassemia, and glomerulonephritis. Several studies suggested that an alteration in CNV-miRNA interaction could result in some human diseases such as cancer. Therefore, the possible miRNA-binding site information within the CNV genes opens new avenues in understanding such disorders. In this chapter, we present a schematic approach for collecting the information on CNV-miRNA interactions using miRWalk and TargetScan databases.

KW - 3'-UTR

KW - CNV-miRNA interaction predictions

KW - Copy number variant

KW - MicroRNA

KW - miRWalk

UR - http://www.scopus.com/inward/record.url?scp=84925883658&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-1062-5_26

DO - 10.1007/978-1-4939-1062-5_26

M3 - Chapter

C2 - 25055921

AN - SCOPUS:84925883658

SN - 9781493910618

VL - 1182

T3 - Methods in Molecular Biology

SP - 307

EP - 320

BT - RNA Mapping

PB - Humana Press Inc.

ER -

A schematic workflow for collecting information about the interaction between copy number variants and MicroRNAs using existing resources

Abstract

Publication series

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this