Abnormal T-Lymphocyte Subsets in Hemophilia: Relation to HLA Proteins in Plasma Products

Christine A. Lee, P. B.A. Kernoff, Peter Karayiannis, Jenny Waters, H. C. Thomas

Research output: Contribution to journalLetter

10 Citations (Scopus)

Abstract

To the Editor: It seems beyond doubt that infusions of blood products are mainly responsible for the T-lymphocyte abnormalities and immune deficiency reported in hemophiliacs.1,2 We have found that abnormalities of T-cell-subset distribution, characterized by low helper-to-cytotoxic/suppressor T-lymphocyte ratios (T4/T8 ratios), are more common in hemophiliacs who have had a high exposure to factor VIII.3 In contrast, patients who have been treated with large quantities of factor IX more commonly have normal ratios.3 4 5 Opelz et al. first showed that transfusion of leukocytes into renal-allograft recipients enhanced the acceptance rate,6 and it has been suggested that this apparent immune suppression may.

Original languageEnglish
Pages (from-to)1058
Number of pages1
JournalNew England Journal of Medicine
Volume310
Issue number16
DOIs
Publication statusPublished - 19 Apr 1984

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