TY - JOUR
T1 - Abnormal T-Lymphocyte Subsets in Hemophilia
T2 - Relation to HLA Proteins in Plasma Products
AU - Lee, Christine A.
AU - Kernoff, P. B.A.
AU - Karayiannis, Peter
AU - Waters, Jenny
AU - Thomas, H. C.
PY - 1984/4/19
Y1 - 1984/4/19
N2 - To the Editor: It seems beyond doubt that infusions of blood products are mainly responsible for the T-lymphocyte abnormalities and immune deficiency reported in hemophiliacs.1,2 We have found that abnormalities of T-cell-subset distribution, characterized by low helper-to-cytotoxic/suppressor T-lymphocyte ratios (T4/T8 ratios), are more common in hemophiliacs who have had a high exposure to factor VIII.3 In contrast, patients who have been treated with large quantities of factor IX more commonly have normal ratios.3 4 5 Opelz et al. first showed that transfusion of leukocytes into renal-allograft recipients enhanced the acceptance rate,6 and it has been suggested that this apparent immune suppression may.
AB - To the Editor: It seems beyond doubt that infusions of blood products are mainly responsible for the T-lymphocyte abnormalities and immune deficiency reported in hemophiliacs.1,2 We have found that abnormalities of T-cell-subset distribution, characterized by low helper-to-cytotoxic/suppressor T-lymphocyte ratios (T4/T8 ratios), are more common in hemophiliacs who have had a high exposure to factor VIII.3 In contrast, patients who have been treated with large quantities of factor IX more commonly have normal ratios.3 4 5 Opelz et al. first showed that transfusion of leukocytes into renal-allograft recipients enhanced the acceptance rate,6 and it has been suggested that this apparent immune suppression may.
UR - http://www.scopus.com/inward/record.url?scp=0021227231&partnerID=8YFLogxK
U2 - 10.1056/NEJM198404193101616
DO - 10.1056/NEJM198404193101616
M3 - Letter
C2 - 6424010
AN - SCOPUS:0021227231
SN - 0028-4793
VL - 310
SP - 1058
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 16
ER -