Acute administration of alprazolam has no effect on plasma homovanillic acid concentration in normal subjects

Zvi Zemishlany; Michael Davidson; Stacey Jaff; Robert McQueeney

doi:10.1016/0920-9964(91)90056-W

Acute administration of alprazolam has no effect on plasma homovanillic acid concentration in normal subjects

Zvi Zemishlany
, Michael Davidson
, Stacey Jaff
, Robert McQueeney

Research output: Contribution to journal › Article › peer-review

Abstract

Alprazolam has been suggested as an adjuvant to neuroleptic drugs in the treatment of schizophrenic patients. In an attempt to investigate whether alprazolam has an effect on dopaminergic neurotransmission, plasma homovanillic acid concentrations were measured for 24 h following a challenge with 3 mg of alprazolam or placebo in eight healthy subjects. Alprazolam had no effect on plasma homovanillic acid which may suggest that this agent is devoid of activity at the dopaminergic system in normal subjects.

Original language	English
Pages (from-to)	81-83
Number of pages	3
Journal	Schizophrenia Research
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/0920-9964(91)90056-W
Publication status	Published - 1991
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

(Schizophrenia)
Alprazolam
Plasma homovanillic acid

Access to Document

10.1016/0920-9964(91)90056-W

Cite this

@article{e64405f8a8454e339b327bc1801d5c4f,

title = "Acute administration of alprazolam has no effect on plasma homovanillic acid concentration in normal subjects",

abstract = "Alprazolam has been suggested as an adjuvant to neuroleptic drugs in the treatment of schizophrenic patients. In an attempt to investigate whether alprazolam has an effect on dopaminergic neurotransmission, plasma homovanillic acid concentrations were measured for 24 h following a challenge with 3 mg of alprazolam or placebo in eight healthy subjects. Alprazolam had no effect on plasma homovanillic acid which may suggest that this agent is devoid of activity at the dopaminergic system in normal subjects.",

keywords = "(Schizophrenia), Alprazolam, Plasma homovanillic acid",

author = "Zvi Zemishlany and Michael Davidson and Stacey Jaff and Robert McQueeney",

year = "1991",

doi = "10.1016/0920-9964(91)90056-W",

language = "English",

volume = "5",

pages = "81--83",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier BV",

number = "1",

}

TY - JOUR

T1 - Acute administration of alprazolam has no effect on plasma homovanillic acid concentration in normal subjects

AU - Zemishlany, Zvi

AU - Davidson, Michael

AU - Jaff, Stacey

AU - McQueeney, Robert

PY - 1991

Y1 - 1991

N2 - Alprazolam has been suggested as an adjuvant to neuroleptic drugs in the treatment of schizophrenic patients. In an attempt to investigate whether alprazolam has an effect on dopaminergic neurotransmission, plasma homovanillic acid concentrations were measured for 24 h following a challenge with 3 mg of alprazolam or placebo in eight healthy subjects. Alprazolam had no effect on plasma homovanillic acid which may suggest that this agent is devoid of activity at the dopaminergic system in normal subjects.

AB - Alprazolam has been suggested as an adjuvant to neuroleptic drugs in the treatment of schizophrenic patients. In an attempt to investigate whether alprazolam has an effect on dopaminergic neurotransmission, plasma homovanillic acid concentrations were measured for 24 h following a challenge with 3 mg of alprazolam or placebo in eight healthy subjects. Alprazolam had no effect on plasma homovanillic acid which may suggest that this agent is devoid of activity at the dopaminergic system in normal subjects.

KW - (Schizophrenia)

KW - Alprazolam

KW - Plasma homovanillic acid

UR - https://www.scopus.com/pages/publications/0025804803

U2 - 10.1016/0920-9964(91)90056-W

DO - 10.1016/0920-9964(91)90056-W

M3 - Article

C2 - 1677266

AN - SCOPUS:0025804803

SN - 0920-9964

VL - 5

SP - 81

EP - 83

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1

ER -

Acute administration of alprazolam has no effect on plasma homovanillic acid concentration in normal subjects

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this