Abstract
In this study we investigate the use of multiscale Amplitude Modulation-Frequency Modulation (AM-FM) methods for analyzing brain white matter lesions that are associated with multiple sclerosis MRI lesions imaged at 0 and 6-12 months. We use the instantaneous amplitude (IA) and the instantaneous frequency (IF) to assess disease progression. The IA and the IF were calculated in transverse sections of T2- weighted magnetic resonance (MR) images acquired from 38 symptomatic untreated subjects between the first and the second examination scan. The findings suggest that the high-, medium-, and low- frequency scale instantaneous amplitude and frequency can be used to differentiate between normal tissue and lesions at 0 and 6-12 months. Moreover, support vector machine (SVM) models gave satisfactory results for differentiating lesions at 0 months using the medium scale IA and IF components for expanded disability status scale (EDSS) <=2 and EDSS >2. Further work is needed with more subjects in validating the proposed AM-FM analysis.
Original language | English |
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Title of host publication | XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010, MEDICON 2010 |
Pages | 446-449 |
Number of pages | 4 |
Volume | 29 |
DOIs | |
Publication status | Published - 2010 |
Event | 12th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2010 - Chalkidiki, Greece Duration: 27 May 2010 → 30 May 2010 |
Other
Other | 12th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2010 |
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Country/Territory | Greece |
City | Chalkidiki |
Period | 27/05/10 → 30/05/10 |
Keywords
- AM-FM analysis
- brain white matter
- disease progression
- Multiple sclerosis