An alpha2 adrenoceptor antagonist, Org 3770, enhances nocturnal melatonin secretion in man

E. Palazidou, A. Papadopoulos, A. Sitsen, S. Stahl, S. Checkley

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28 Citations (Scopus)

Abstract

Nocturnal plasma melatonin concentration was significantly increased in ten normal volunteers following the administration of an alpha2 adrenoceptor antagonist, Org 3770 (30 mg). This result supports the existence of an alpha2 adrenergic influence on melatonin secretion in man and provides a possible clinical neuroendocrine marker of the action of an alpha2 antagonist.

Original languageEnglish
Pages (from-to)115-117
Number of pages3
JournalPsychopharmacology
Volume97
Issue number1
DOIs
Publication statusPublished - Jan 1989

Keywords

  • Alpha adrenoceptor blockade
  • Melatonin secretion

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    Palazidou, E., Papadopoulos, A., Sitsen, A., Stahl, S., & Checkley, S. (1989). An alpha2 adrenoceptor antagonist, Org 3770, enhances nocturnal melatonin secretion in man. Psychopharmacology, 97(1), 115-117. https://doi.org/10.1007/BF00443424