An alpha2 adrenoceptor antagonist, Org 3770, enhances nocturnal melatonin secretion in man

E. Palazidou, A. Papadopoulos, A. Sitsen, S. Stahl, S. Checkley

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Nocturnal plasma melatonin concentration was significantly increased in ten normal volunteers following the administration of an alpha2 adrenoceptor antagonist, Org 3770 (30 mg). This result supports the existence of an alpha2 adrenergic influence on melatonin secretion in man and provides a possible clinical neuroendocrine marker of the action of an alpha2 antagonist.

Original languageEnglish
Pages (from-to)115-117
Number of pages3
JournalPsychopharmacology
Volume97
Issue number1
DOIs
Publication statusPublished - Jan 1989

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Melatonin
Adrenergic Receptors
Adrenergic Agents
Healthy Volunteers
Biomarkers

Keywords

  • Alpha adrenoceptor blockade
  • Melatonin secretion

Cite this

Palazidou, E., Papadopoulos, A., Sitsen, A., Stahl, S., & Checkley, S. (1989). An alpha2 adrenoceptor antagonist, Org 3770, enhances nocturnal melatonin secretion in man. Psychopharmacology, 97(1), 115-117. https://doi.org/10.1007/BF00443424
Palazidou, E. ; Papadopoulos, A. ; Sitsen, A. ; Stahl, S. ; Checkley, S. / An alpha2 adrenoceptor antagonist, Org 3770, enhances nocturnal melatonin secretion in man. In: Psychopharmacology. 1989 ; Vol. 97, No. 1. pp. 115-117.
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Palazidou, E, Papadopoulos, A, Sitsen, A, Stahl, S & Checkley, S 1989, 'An alpha2 adrenoceptor antagonist, Org 3770, enhances nocturnal melatonin secretion in man', Psychopharmacology, vol. 97, no. 1, pp. 115-117. https://doi.org/10.1007/BF00443424

An alpha2 adrenoceptor antagonist, Org 3770, enhances nocturnal melatonin secretion in man. / Palazidou, E.; Papadopoulos, A.; Sitsen, A.; Stahl, S.; Checkley, S.

In: Psychopharmacology, Vol. 97, No. 1, 01.1989, p. 115-117.

Research output: Contribution to journalArticle

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