Angelman's syndrome: a neuropathological study

T. Kyriakides, L. A. Hallam, A. Hockey, P. Silberstein, B. A. Kakulas

Research output: Contribution to journalArticlepeer-review

Abstract

We report the neuropathological findings of a 3-year-old boy with Angelman's syndrome. The main abnormalities were macroscopic consisting of small temporal and frontal lobes which also showed disorganised and irregular gyri. The occipital lobes appeared flattened but were otherwise normal as were the parietal lobes. The brain stem and cerebellum appeared normal externally. Microscopically there was irregular distribution of neurons in layer 3 and in the cerebral white matter a few subcortical ectopic neurons were present in the temporal and frontal lobes. A single "Purkinje" cell heterotopia was seen but otherwise the cerebellum appeared normal.

Original languageEnglish
Pages (from-to)675-678
Number of pages4
JournalActa Neuropathologica
Volume83
Issue number6
DOIs
Publication statusPublished - May 1992

Keywords

  • Angelman's syndrome
  • Neuropathology

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