Antibiotic consumption and resistance during a 3-year period in Sicily, Southern Italy

Martina Barchitta, Annalisa Quattrocchi, Andrea Maugeri, Maria Clara La Rosa, Claudia La Mastra, Laura Sessa, Pasquale Cananzi, Giuseppe Murolo, Alessandro Oteri, Guido Basile, Antonella Agodi

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Antimicrobial resistance (AMR) is one of the biggest issues facing global public health. In 2017, Italy adopted its first National Action Plan on Antimicrobial Resistance 2017–2020, which works through the synergy between national, regional, and local levels. In the framework of a Regional Action Plan on healthcare-associated infections and AMR prevention, the Sicilian Health Authority of the Sicilian Region, Southern Italy, has implemented a surveillance system of antibiotic consumption in hospitals, in the community, and of resistance rates (RRs) in hospital settings. Data on antibiotic consumption and on antibiotic RRs have been collected from 2015 to 2017 from pharmacies and laboratories of participating hospitals and from community, respectively. Data on antibiotic consumption showed that the most consumed antibiotics in hospitals were fluoroquinolones in 2015, penicillin in 2016, and beta-lactams in 2017. From 2015 to 2017, data on Klebsiella pneumoniae showed significant increasing RRs to all antibiotic classes, except to carbapenems. RRs of third-generation cephalosporins and carbapenems Escherichia coli showed significant decreasing trends. RRs of the other microorganisms did not change significantly during the study period. The results from the present study show that in Sicily, the use of antibiotics and RRs for selected microorganisms are at a high level. Immediate strategies are needed to decrease the inappropriate usage of antibiotics and control the spread of AMR.

Original languageEnglish
Article number2253
JournalInternational Journal of Environmental Research and Public Health
Volume16
Issue number13
DOIs
Publication statusPublished - 1 Jul 2019
Externally publishedYes

Keywords

  • Defined daily dose
  • Indicators
  • Public health
  • Resistance rates
  • Surveillance

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