Breakthrough SARS-CoV-2 infections after vaccination: a critical review

Zeinab Mohseni Afshar, Mohammad Barary, Rezvan Hosseinzadeh, Amirmasoud Alijanpour, Dariush Hosseinzadeh, Soheil Ebrahimpour, Kosar Nazary, Terence T. Sio, Mark J.M. Sullman, Kristin Carson-Chahhoud, Arefeh Babazadeh

Research output: Contribution to journalArticlepeer-review


At the beginning of the current pandemic, it was believed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection would induce lifelong immunity and that reinfections would be unlikely. However, after several cases of reinfection were documented in previously infected patients, this was understood to be a false assumption, and this waning humoral immunity has raised significant concerns. Accordingly, long-term and durable vaccine-induced antibody protection against infection have also become a challenge, as several breakthroughs of COVID-19 infection have been identified in individuals who were fully vaccinated. This review discusses the current evidence on breakthrough COVID-19 infections occurring after vaccination.

Original languageEnglish
JournalHuman Vaccines and Immunotherapeutics
Publication statusAccepted/In press - 2022


  • breakthrough
  • COVID-19
  • immunization
  • SARS-CoV-2
  • vaccination


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