Breakthrough SARS-CoV-2 infections after vaccination: a critical review

Zeinab Mohseni Afshar; Mohammad Barary; Rezvan Hosseinzadeh; Amirmasoud Alijanpour; Dariush Hosseinzadeh; Soheil Ebrahimpour; Kosar Nazary; Terence T. Sio; Mark J.M. Sullman; Kristin Carson-Chahhoud; Arefeh Babazadeh

doi:10.1080/21645515.2022.2051412

Breakthrough SARS-CoV-2 infections after vaccination: a critical review

Zeinab Mohseni Afshar
, Mohammad Barary
, Rezvan Hosseinzadeh
, Amirmasoud Alijanpour
, Dariush Hosseinzadeh
, Soheil Ebrahimpour
, Kosar Nazary
, Terence T. Sio
, Mark J.M. Sullman
, Kristin Carson-Chahhoud
, Arefeh Babazadeh

Research output: Contribution to journal › Review article › peer-review

Abstract

At the beginning of the current pandemic, it was believed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection would induce lifelong immunity and that reinfections would be unlikely. However, after several cases of reinfection were documented in previously infected patients, this was understood to be a false assumption, and this waning humoral immunity has raised significant concerns. Accordingly, long-term and durable vaccine-induced antibody protection against infection have also become a challenge, as several breakthroughs of COVID-19 infection have been identified in individuals who were fully vaccinated. This review discusses the current evidence on breakthrough COVID-19 infections occurring after vaccination.

Original language	English
Article number	2051412
Journal	Human Vaccines and Immunotherapeutics
Volume	18
Issue number	5
DOIs	https://doi.org/10.1080/21645515.2022.2051412
Publication status	Published - 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

breakthrough
COVID-19
immunization
SARS-CoV-2
vaccination

Access to Document

10.1080/21645515.2022.2051412

Cite this

Mohseni Afshar, Z., Barary, M., Hosseinzadeh, R., Alijanpour, A., Hosseinzadeh, D., Ebrahimpour, S., Nazary, K., Sio, T. T., Sullman, M. J. M., Carson-Chahhoud, K., & Babazadeh, A. (2022). Breakthrough SARS-CoV-2 infections after vaccination: a critical review. Human Vaccines and Immunotherapeutics, 18(5), Article 2051412. https://doi.org/10.1080/21645515.2022.2051412

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title = "Breakthrough SARS-CoV-2 infections after vaccination: a critical review",

abstract = "At the beginning of the current pandemic, it was believed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection would induce lifelong immunity and that reinfections would be unlikely. However, after several cases of reinfection were documented in previously infected patients, this was understood to be a false assumption, and this waning humoral immunity has raised significant concerns. Accordingly, long-term and durable vaccine-induced antibody protection against infection have also become a challenge, as several breakthroughs of COVID-19 infection have been identified in individuals who were fully vaccinated. This review discusses the current evidence on breakthrough COVID-19 infections occurring after vaccination.",

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doi = "10.1080/21645515.2022.2051412",

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AU - Mohseni Afshar, Zeinab

AU - Barary, Mohammad

AU - Hosseinzadeh, Rezvan

AU - Alijanpour, Amirmasoud

AU - Hosseinzadeh, Dariush

AU - Ebrahimpour, Soheil

AU - Nazary, Kosar

AU - Sio, Terence T.

AU - Sullman, Mark J.M.

AU - Carson-Chahhoud, Kristin

AU - Babazadeh, Arefeh

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AB - At the beginning of the current pandemic, it was believed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection would induce lifelong immunity and that reinfections would be unlikely. However, after several cases of reinfection were documented in previously infected patients, this was understood to be a false assumption, and this waning humoral immunity has raised significant concerns. Accordingly, long-term and durable vaccine-induced antibody protection against infection have also become a challenge, as several breakthroughs of COVID-19 infection have been identified in individuals who were fully vaccinated. This review discusses the current evidence on breakthrough COVID-19 infections occurring after vaccination.

KW - breakthrough

KW - COVID-19

KW - immunization

KW - SARS-CoV-2

KW - vaccination

UR - https://www.scopus.com/pages/publications/85126785867

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DO - 10.1080/21645515.2022.2051412

M3 - Review article

C2 - 35302905

AN - SCOPUS:85126785867

SN - 2164-5515

VL - 18

JO - Human Vaccines and Immunotherapeutics

JF - Human Vaccines and Immunotherapeutics

IS - 5

M1 - 2051412

ER -

Breakthrough SARS-CoV-2 infections after vaccination: a critical review

Abstract

UN SDGs

Keywords

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