Candidaemia in a European Paediatric University Hospital: A 10-year observational study

A. Tragiannidis; W. Fegeler; G. Rellensmann; V. Debus; V. Müller; I. Hoernig-Franz; K. Siam; Z. D. Pana; H. Jürgens; A. H. Groll

doi:10.1111/j.1469-0691.2011.03720.x

Candidaemia in a European Paediatric University Hospital: A 10-year observational study

A. Tragiannidis
, W. Fegeler
, G. Rellensmann
, V. Debus
, V. Müller
, I. Hoernig-Franz
, K. Siam
, Z. D. Pana
, H. Jürgens
, A. H. Groll

Research output: Contribution to journal › Article › peer-review

Abstract

In this retrospective observational study covering 1998 to 2008, 32 patients (mean age: 7.50years) were identified that had 35 episodes of candidaemia (0.47 cases/1000 hospital discharges). Cancer/allogeneic haematopoietic stem cell transplantation (43%) and congenital malformations/syndromes (21%) were the predominant underlying conditions. Central venous catheterization (90%), a history of antibacterial therapy (69%) and previous bacteraemia (54%) were frequent comorbidities. Candida albicans (46%) was most common, followed by Candida parapsilosis (17%) and Candida glabrata (14%). Resistance was infrequent and limited to non-albicans Candida spp. The 30-day and 100-day mortality rates were 11.4%.

Original language	English
Pages (from-to)	E27-E30
Journal	Clinical Microbiology and Infection
Volume	18
Issue number	2
DOIs	https://doi.org/10.1111/j.1469-0691.2011.03720.x
Publication status	Published - Feb 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Candidaemia
Epidemiology
Mortality
Mycoses
Paediatrics
Risk factors
Treatment

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10.1111/j.1469-0691.2011.03720.x

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title = "Candidaemia in a European Paediatric University Hospital: A 10-year observational study",

abstract = "In this retrospective observational study covering 1998 to 2008, 32 patients (mean age: 7.50years) were identified that had 35 episodes of candidaemia (0.47 cases/1000 hospital discharges). Cancer/allogeneic haematopoietic stem cell transplantation (43\%) and congenital malformations/syndromes (21\%) were the predominant underlying conditions. Central venous catheterization (90\%), a history of antibacterial therapy (69\%) and previous bacteraemia (54\%) were frequent comorbidities. Candida albicans (46\%) was most common, followed by Candida parapsilosis (17\%) and Candida glabrata (14\%). Resistance was infrequent and limited to non-albicans Candida spp. The 30-day and 100-day mortality rates were 11.4\%.",

keywords = "Candidaemia, Epidemiology, Mortality, Mycoses, Paediatrics, Risk factors, Treatment",

author = "A. Tragiannidis and W. Fegeler and G. Rellensmann and V. Debus and V. M{\"u}ller and I. Hoernig-Franz and K. Siam and Pana, \{Z. D.\} and H. J{\"u}rgens and Groll, \{A. H.\}",

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doi = "10.1111/j.1469-0691.2011.03720.x",

language = "English",

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TY - JOUR

T1 - Candidaemia in a European Paediatric University Hospital

T2 - A 10-year observational study

AU - Tragiannidis, A.

AU - Fegeler, W.

AU - Rellensmann, G.

AU - Debus, V.

AU - Müller, V.

AU - Hoernig-Franz, I.

AU - Siam, K.

AU - Pana, Z. D.

AU - Jürgens, H.

AU - Groll, A. H.

PY - 2012/2

Y1 - 2012/2

N2 - In this retrospective observational study covering 1998 to 2008, 32 patients (mean age: 7.50years) were identified that had 35 episodes of candidaemia (0.47 cases/1000 hospital discharges). Cancer/allogeneic haematopoietic stem cell transplantation (43%) and congenital malformations/syndromes (21%) were the predominant underlying conditions. Central venous catheterization (90%), a history of antibacterial therapy (69%) and previous bacteraemia (54%) were frequent comorbidities. Candida albicans (46%) was most common, followed by Candida parapsilosis (17%) and Candida glabrata (14%). Resistance was infrequent and limited to non-albicans Candida spp. The 30-day and 100-day mortality rates were 11.4%.

AB - In this retrospective observational study covering 1998 to 2008, 32 patients (mean age: 7.50years) were identified that had 35 episodes of candidaemia (0.47 cases/1000 hospital discharges). Cancer/allogeneic haematopoietic stem cell transplantation (43%) and congenital malformations/syndromes (21%) were the predominant underlying conditions. Central venous catheterization (90%), a history of antibacterial therapy (69%) and previous bacteraemia (54%) were frequent comorbidities. Candida albicans (46%) was most common, followed by Candida parapsilosis (17%) and Candida glabrata (14%). Resistance was infrequent and limited to non-albicans Candida spp. The 30-day and 100-day mortality rates were 11.4%.

KW - Candidaemia

KW - Epidemiology

KW - Mortality

KW - Mycoses

KW - Paediatrics

KW - Risk factors

KW - Treatment

UR - https://www.scopus.com/pages/publications/84856235080

U2 - 10.1111/j.1469-0691.2011.03720.x

DO - 10.1111/j.1469-0691.2011.03720.x

M3 - Article

AN - SCOPUS:84856235080

SN - 1198-743X

VL - 18

SP - E27-E30

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 2

ER -

Candidaemia in a European Paediatric University Hospital: A 10-year observational study

Abstract

UN SDGs

Keywords

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