TY - JOUR
T1 - Cardiometabolic risk factors related to non-alcoholic fatty liver disease in obese children
AU - Papandreou, Dimitrios
AU - Karabouta, Zacharoula
AU - Pantoleon, Athina
AU - Sidiropoulou, Athina
AU - Rousso, Israel
PY - 2014
Y1 - 2014
N2 - Purpose: The aim of this study was to investigate the relation of several cardiometabolic risk factors among obese children with and without non-alcoholic fatty liver disease. One hundred-two subjects aged 8-15 years old participated in the study. Methods : Laboratory analysis included fasting blood glucose, serum insulin, serum triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and liver biochemical profile, in addition to liver ultrasound. Results: Forty children (39%) were found to have metabolic syndrome. Insulin resistance was present in 46 (48%) children. Patients with MS were more likely to have non-alcoholic fatty liver disease (P<0.001). Children with Non-alcoholic fatty liver disease had significantly higher body mass index, waist circumference, blood pressure, triglycerides, fasting insulin, and lower high-density lipoprotein compared to patients with normal liver (P< 0.001). Insulin resistance was significantly higher in children with Non-alcoholic fatty liver disease (P<0.001). Obese children presented with MS were 2.42 (95% CI: 2.05, 2.57) times more likely to develop NAFLD compared to those without metabolic syndrome. Conclusions: Obese children with fatty liver may have a higher risk of developing metabolic syndrome and insulin resistance. Weight management and early prevention should be the first line of treatment in order to prevent any possible health issues later on.
AB - Purpose: The aim of this study was to investigate the relation of several cardiometabolic risk factors among obese children with and without non-alcoholic fatty liver disease. One hundred-two subjects aged 8-15 years old participated in the study. Methods : Laboratory analysis included fasting blood glucose, serum insulin, serum triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and liver biochemical profile, in addition to liver ultrasound. Results: Forty children (39%) were found to have metabolic syndrome. Insulin resistance was present in 46 (48%) children. Patients with MS were more likely to have non-alcoholic fatty liver disease (P<0.001). Children with Non-alcoholic fatty liver disease had significantly higher body mass index, waist circumference, blood pressure, triglycerides, fasting insulin, and lower high-density lipoprotein compared to patients with normal liver (P< 0.001). Insulin resistance was significantly higher in children with Non-alcoholic fatty liver disease (P<0.001). Obese children presented with MS were 2.42 (95% CI: 2.05, 2.57) times more likely to develop NAFLD compared to those without metabolic syndrome. Conclusions: Obese children with fatty liver may have a higher risk of developing metabolic syndrome and insulin resistance. Weight management and early prevention should be the first line of treatment in order to prevent any possible health issues later on.
KW - Cardiometabolic risk factors, metabolic syndrome
KW - Children
KW - Insulin resistance
KW - Non-alcoholic fatty liver disease
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=84905856753&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84905856753
SN - 1205-6626
VL - 20
SP - 2194
EP - 2205
JO - Experimental and Clinical Cardiology
JF - Experimental and Clinical Cardiology
IS - 8
ER -