Cardiometabolic risk factors related to non-alcoholic fatty liver disease in obese children

Dimitrios Papandreou, Zacharoula Karabouta, Athina Pantoleon, Athina Sidiropoulou, Israel Rousso

Research output: Contribution to journalArticlepeer-review


Purpose: The aim of this study was to investigate the relation of several cardiometabolic risk factors among obese children with and without non-alcoholic fatty liver disease. One hundred-two subjects aged 8-15 years old participated in the study. Methods : Laboratory analysis included fasting blood glucose, serum insulin, serum triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and liver biochemical profile, in addition to liver ultrasound. Results: Forty children (39%) were found to have metabolic syndrome. Insulin resistance was present in 46 (48%) children. Patients with MS were more likely to have non-alcoholic fatty liver disease (P<0.001). Children with Non-alcoholic fatty liver disease had significantly higher body mass index, waist circumference, blood pressure, triglycerides, fasting insulin, and lower high-density lipoprotein compared to patients with normal liver (P< 0.001). Insulin resistance was significantly higher in children with Non-alcoholic fatty liver disease (P<0.001). Obese children presented with MS were 2.42 (95% CI: 2.05, 2.57) times more likely to develop NAFLD compared to those without metabolic syndrome. Conclusions: Obese children with fatty liver may have a higher risk of developing metabolic syndrome and insulin resistance. Weight management and early prevention should be the first line of treatment in order to prevent any possible health issues later on.

Original languageEnglish
Pages (from-to)2194-2205
Number of pages12
JournalExperimental and Clinical Cardiology
Issue number8
Publication statusPublished - 2014


  • Cardiometabolic risk factors, metabolic syndrome
  • Children
  • Insulin resistance
  • Non-alcoholic fatty liver disease
  • Obesity


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