Cerebral oxygenation and optimal vascular brain organization

Constantinos Hadjistassou, Adrian Bejan, Yiannis Ventikos

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The cerebral vascular network has evolved in such a way so as to minimize transport time and energy expenditure. This is accomplished by a subtle combination of the optimal arrangement of arteries, arterioles and capillaries and the transport mechanisms of convection and diffusion. Elucidating the interaction between cerebral vascular architectonics and the latter physical mechanisms can catalyse progress in treating cerebral pathologies such as stroke, brain tumours, dementia and targeted drug delivery. Here, we show that brain microvascular organization is predicated on commensurate intracapillary oxygen convection and parenchymal diffusion times. Cross-species grey matter results for the rat, cat, rabbit and human reveal very good correlation between the cerebral capillary and tissue mean axial oxygen convective and diffusion time intervals. These findings agree with the constructal principle.

Original languageEnglish
Article number20150245
JournalJournal of the Royal Society Interface
Volume12
Issue number107
DOIs
Publication statusPublished - 6 Jun 2015

Keywords

  • Diffusion and convection time
  • Mammalian vascular architecture
  • Optimal
  • Oxygen

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