Characterization of new drug delivery nanosystems using atomic force microscopy

Ellas Spyratou; Elena A. Mourelatou; C. Demetzos; Mersini Makropoulou; A. A. Serafetinides

doi:10.1117/12.2178483

Characterization of new drug delivery nanosystems using atomic force microscopy

Ellas Spyratou, Elena A. Mourelatou, C. Demetzos, Mersini Makropoulou, A. A. Serafetinides

School of Life and Health Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Liposomes are the most attractive lipid vesicles for targeted drug delivery in nanomedicine, behaving also as cell models in biophotonics research. The characterization of the micro-mechanical properties of drug carriers is an important issue and many analytical techniques are employed, as, for example, optical tweezers and atomic force microscopy. In this work, polyol hyperbranched polymers (HBPs) have been employed along with liposomes for the preparation of new chimeric advanced drug delivery nanosystems (Chi-aDDnSs). Aliphatic polyester HBPs with three different pseudogenerations G2, G3 and G4 with 16, 32, and 64 peripheral hydroxyl groups, respectively, have been incorporated in liposomal formulation. The atomic force microscopy (AFM) technique was used for the comparative study of the morphology and the mechanical properties of Chi-aDDnSs and conventional DDnS. The effects of both the HBPs architecture and the polyesters pseudogeneration number in the stability and the stiffness of chi-aDDnSs were examined. From the force-distance curves of AFM spectroscopy, the Young's modulus was calculated.

Original language	English
Title of host publication	18th International School on Quantum Electronics
Subtitle of host publication	Laser Physics and Applications
Publisher	SPIE
Volume	9447
ISBN (Electronic)	9781628415636
DOIs	https://doi.org/10.1117/12.2178483
Publication status	Published - 2015
Event	18th International School on Quantum Electronics: Laser Physics and Applications, ISQE 2014 - Sozopol, Bulgaria Duration: 29 Sept 2014 → 3 Oct 2014

Other

Other	18th International School on Quantum Electronics: Laser Physics and Applications, ISQE 2014
Country/Territory	Bulgaria
City	Sozopol
Period	29/09/14 → 3/10/14

Keywords

AFM force spectroscopy
Drug delivery nanosystems
Hyperbranched polymers
Liposome mechanical properties

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10.1117/12.2178483

Cite this

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title = "Characterization of new drug delivery nanosystems using atomic force microscopy",

abstract = "Liposomes are the most attractive lipid vesicles for targeted drug delivery in nanomedicine, behaving also as cell models in biophotonics research. The characterization of the micro-mechanical properties of drug carriers is an important issue and many analytical techniques are employed, as, for example, optical tweezers and atomic force microscopy. In this work, polyol hyperbranched polymers (HBPs) have been employed along with liposomes for the preparation of new chimeric advanced drug delivery nanosystems (Chi-aDDnSs). Aliphatic polyester HBPs with three different pseudogenerations G2, G3 and G4 with 16, 32, and 64 peripheral hydroxyl groups, respectively, have been incorporated in liposomal formulation. The atomic force microscopy (AFM) technique was used for the comparative study of the morphology and the mechanical properties of Chi-aDDnSs and conventional DDnS. The effects of both the HBPs architecture and the polyesters pseudogeneration number in the stability and the stiffness of chi-aDDnSs were examined. From the force-distance curves of AFM spectroscopy, the Young's modulus was calculated.",

keywords = "AFM force spectroscopy, Drug delivery nanosystems, Hyperbranched polymers, Liposome mechanical properties",

author = "Ellas Spyratou and Mourelatou, {Elena A.} and C. Demetzos and Mersini Makropoulou and Serafetinides, {A. A.}",

year = "2015",

doi = "10.1117/12.2178483",

language = "English",

volume = "9447",

booktitle = "18th International School on Quantum Electronics",

publisher = "SPIE",

note = "18th International School on Quantum Electronics: Laser Physics and Applications, ISQE 2014 ; Conference date: 29-09-2014 Through 03-10-2014",

}

Spyratou, E, Mourelatou, EA, Demetzos, C, Makropoulou, M & Serafetinides, AA 2015, Characterization of new drug delivery nanosystems using atomic force microscopy. in 18th International School on Quantum Electronics: Laser Physics and Applications. vol. 9447, 944714, SPIE, 18th International School on Quantum Electronics: Laser Physics and Applications, ISQE 2014, Sozopol, Bulgaria, 29/09/14. https://doi.org/10.1117/12.2178483

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AU - Spyratou, Ellas

AU - Mourelatou, Elena A.

AU - Demetzos, C.

AU - Makropoulou, Mersini

AU - Serafetinides, A. A.

PY - 2015

Y1 - 2015

N2 - Liposomes are the most attractive lipid vesicles for targeted drug delivery in nanomedicine, behaving also as cell models in biophotonics research. The characterization of the micro-mechanical properties of drug carriers is an important issue and many analytical techniques are employed, as, for example, optical tweezers and atomic force microscopy. In this work, polyol hyperbranched polymers (HBPs) have been employed along with liposomes for the preparation of new chimeric advanced drug delivery nanosystems (Chi-aDDnSs). Aliphatic polyester HBPs with three different pseudogenerations G2, G3 and G4 with 16, 32, and 64 peripheral hydroxyl groups, respectively, have been incorporated in liposomal formulation. The atomic force microscopy (AFM) technique was used for the comparative study of the morphology and the mechanical properties of Chi-aDDnSs and conventional DDnS. The effects of both the HBPs architecture and the polyesters pseudogeneration number in the stability and the stiffness of chi-aDDnSs were examined. From the force-distance curves of AFM spectroscopy, the Young's modulus was calculated.

AB - Liposomes are the most attractive lipid vesicles for targeted drug delivery in nanomedicine, behaving also as cell models in biophotonics research. The characterization of the micro-mechanical properties of drug carriers is an important issue and many analytical techniques are employed, as, for example, optical tweezers and atomic force microscopy. In this work, polyol hyperbranched polymers (HBPs) have been employed along with liposomes for the preparation of new chimeric advanced drug delivery nanosystems (Chi-aDDnSs). Aliphatic polyester HBPs with three different pseudogenerations G2, G3 and G4 with 16, 32, and 64 peripheral hydroxyl groups, respectively, have been incorporated in liposomal formulation. The atomic force microscopy (AFM) technique was used for the comparative study of the morphology and the mechanical properties of Chi-aDDnSs and conventional DDnS. The effects of both the HBPs architecture and the polyesters pseudogeneration number in the stability and the stiffness of chi-aDDnSs were examined. From the force-distance curves of AFM spectroscopy, the Young's modulus was calculated.

KW - AFM force spectroscopy

KW - Drug delivery nanosystems

KW - Hyperbranched polymers

KW - Liposome mechanical properties

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DO - 10.1117/12.2178483

M3 - Conference contribution

AN - SCOPUS:84922730063

VL - 9447

BT - 18th International School on Quantum Electronics

PB - SPIE

T2 - 18th International School on Quantum Electronics: Laser Physics and Applications, ISQE 2014

Y2 - 29 September 2014 through 3 October 2014

ER -

Characterization of new drug delivery nanosystems using atomic force microscopy

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