Cheminformatics and virtual screening studies of COMT inhibitors as potential Parkinson’s disease therapeutics

Keyphrases

• Area Cover 20%
• Aromatic Amino Acid Decarboxylase 20%
• Catechol 20%
• Catechol-O-methyltransferase 20%
• Catechol-O-methyltransferase Inhibitors 100%
• Catecholamines 20%
• Cheminformatics 100%
• Cheminformatics Tools 20%
• Clinical Benefit 20%
• Computational Study 20%
• Diseases Therapeutic 100%
• Dopamine 60%
• Dopamine Metabolism 20%
• Dopaminergic Neurons 20%
• Expert Opinion 20%
• Hydroxyl Group 20%
• Improved Efficacy 20%
• In Silico 20%
• In Silico Methods 20%
• Inhibitor Treatment 20%
• Irreversible Inhibitor 20%
• Levodopa 20%
• Metabolism 20%
• Methylation 20%
• Motor Symptoms 20%
• Nervous System Diseases 20%
• Neurodegeneration 20%
• Neurodegenerative 20%
• Neurological Diseases 20%
• Parkinson's Disease 100%
• Screening Study 100%
• Striatal Dopamine Level 20%
• Virtual Screening 100%

Pharmacology, Toxicology and Pharmaceutical Science

• Adjuvant 14%
• Bioavailability 14%
• Catechol 100%
• Catecholamine 14%
• Central Nervous System Disease 14%
• DOPA Decarboxylase Inhibitor 14%
• Dopamine Receptor Stimulating Agent 14%
• Hydroxyl Group 14%
• Levodopa 14%
• Methyltransferase 28%
• Methyltransferase Inhibitor 100%
• Nerve Cell Degeneration 14%
• Neurologic Disease 14%
• Parkinson's Disease 100%
• Virtual Screening 100%