Chromium coordination compounds with antimicrobial activity: Synthetic routes, structural characteristics, and antibacterial activity

Manolis C. Vlasiou, Kyriaki S. Pafiti

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

A major threat to public health worldwide is that the antimicrobial activity of the established drugs is constantly reduced due to the resistance that bacteria develop throughout the years. Some transition metal complexes show higher antibacterial activity against several bacteria compared to those of clinically used antibiotics. Novel classes of molecules provide new challenges and seem promising to solve the crisis that the overuse of antibiotics has led over the last years. This review discusses the challenges of chromium-based metallodrugs as antimicrobial agents. In particular, the synthetic routes, the structural characteristics, as well as the antimicrobial activity of 32 chromium (III) complexes have been presented.

Original languageEnglish
Pages (from-to)1-25
Number of pages25
JournalOpen Medicinal Chemistry Journal
Volume14
DOIs
Publication statusPublished - 1 Jan 2020

Keywords

  • Antimicrobial
  • Chromium
  • Coordinated compounds
  • Structure
  • Transition Metal Complexes

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