Despite the potential for artificial intelligence (AI)-enabled technologies in healthcare, their benefits are limited owing to the numerous challenges of cognitive engagement. This research paper explores the factors of “cognitive engagement with AI-enabled technologies” and its impact on the customers' benefits and value creation. A mixed-method study was utilized in the Indian health-care setup where AI-based technology is developing. The qualitative findings shed light on the factors of cognitive engagement with AI-enabled technologies. Grounded on the theories of customer benefit, an integrative framework of customer-perceived financial, experiential, psychological, and functional benefits, alongside perceived instrumental and terminal values, was developed. The quantitative findings of PLS-SEM explain the dynamics of the patients' cognitive engagement with AI-enabled technologies. The results enrich a more nuanced understanding of how the patient benefits of AI applications have different impacts on perceived value. The study concludes with theoretical and practical implications.