TY - JOUR
T1 - Comparison between nafarelin acetate and d-Trp6-LHRH for temporary pituitary suppression in in vitro fertilization (IVF) patients
T2 - A prospective crossover study
AU - Tanos, Vasilios
AU - Friedler, Shevach
AU - Shushan, Asher
AU - Strauss, Nurith
AU - Hetsroni, Iftach
AU - Lewin, Aby
PY - 1995/11
Y1 - 1995/11
N2 - Purpose: Nafarelin acetate is a new gonadotropin releasing (GnRH) agonist analogue with unique potency, intranasal administration, and convenient storage. Hence, nafarelin was considered as an alternative for temporary pituitary suppression in patients undergoing ovulation induction in IVF. A crossover treatment in a prospective study was performed including 40 women with bilateral obstructed tubes and normal ovarian function, treated in 80 ovulation induction cycles using the long protocol. Twenty patients used nafarelin acetate 600 Μg/daily in their first cycle and receivedd-Trp6-LHRH, 0.5 mg/daily, in their following cycle. The other 20 women used decapeptyl in their first cycle and received nafarelin in the second. Results: Estradiol suppression was achieved by bothd-Trp6-LHRH and nafarelin at equal time intervals. The average total number of ampoules (P=0.0005) and the length of administration of hMG required for ovarian stimulation (P=0.0002) and the time interval between GnRHa initiation to oocyte retrieval (P=0.04) was significantly lower in nafarelin cycles. The number and the distribution between large and small follicles as well as the average number of oocytes retrieved did not differ between the two GnRH analogues. Conclusion: Our results demonstrate that nafarelin acetate is comparable tod-Trp6-LHRH for temporary pituitary suppression used for controlled ovarian stimulation in IVF patients. However, using nafarelin ovarian stimulation was achieved with fewer ampoules of hMG, administered for a shorter period of time, thus with a lesser cost.
AB - Purpose: Nafarelin acetate is a new gonadotropin releasing (GnRH) agonist analogue with unique potency, intranasal administration, and convenient storage. Hence, nafarelin was considered as an alternative for temporary pituitary suppression in patients undergoing ovulation induction in IVF. A crossover treatment in a prospective study was performed including 40 women with bilateral obstructed tubes and normal ovarian function, treated in 80 ovulation induction cycles using the long protocol. Twenty patients used nafarelin acetate 600 Μg/daily in their first cycle and receivedd-Trp6-LHRH, 0.5 mg/daily, in their following cycle. The other 20 women used decapeptyl in their first cycle and received nafarelin in the second. Results: Estradiol suppression was achieved by bothd-Trp6-LHRH and nafarelin at equal time intervals. The average total number of ampoules (P=0.0005) and the length of administration of hMG required for ovarian stimulation (P=0.0002) and the time interval between GnRHa initiation to oocyte retrieval (P=0.04) was significantly lower in nafarelin cycles. The number and the distribution between large and small follicles as well as the average number of oocytes retrieved did not differ between the two GnRH analogues. Conclusion: Our results demonstrate that nafarelin acetate is comparable tod-Trp6-LHRH for temporary pituitary suppression used for controlled ovarian stimulation in IVF patients. However, using nafarelin ovarian stimulation was achieved with fewer ampoules of hMG, administered for a shorter period of time, thus with a lesser cost.
KW - controlled ovarian stimulation
KW - gonadotropin releasing hormone analogues
KW - in vitro fertilization
KW - nafarelin acetate
KW - pituitary suppression
UR - http://www.scopus.com/inward/record.url?scp=0028856353&partnerID=8YFLogxK
U2 - 10.1007/BF02212899
DO - 10.1007/BF02212899
M3 - Article
C2 - 8624429
AN - SCOPUS:0028856353
SN - 1058-0468
VL - 12
SP - 715
EP - 719
JO - Journal of Assisted Reproduction and Genetics
JF - Journal of Assisted Reproduction and Genetics
IS - 10
ER -