Computational identification of metabolites for pathways related to huntington's disease

Christiana Christodoulou, George Minadakis, Christiana Demetriou, Eleni Zamba-Papanicolaou, George Spyrou

    Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

    Abstract

    Huntington's disease (HD), a rare autosomal dominant disease, affecting the medium spiny neurons of the CNS. Although HD is caused by a trinucleotide repeat in the HTT gene, it is a complex disease. Systems Bioinformatics which combines systems biology and bioinformatics, has the ability to reveal synergistic relationships between multiple entities. This approach is vital as it can shed light on the biological behavior and mechanisms of the cell rather than only trying to study and understand a part of the system. Metabolomics is the systematic study and measurement of metabolites within a biological sample. In this work, we employ two approaches to identify metabolites for HD-related pathways, which were previously identified from our previous work on multi-source data integration These include: i) creation of pathway-to-pathway networks based on the reference network of PathwayConnector where pathways are mapped based on connectivity on KEGG, and (ii) creation of pathway-to-pathway networks using a pairwise approach, where a connection between two pathways exists only if they share common metabolites.

    Original languageEnglish
    Title of host publicationProceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019
    PublisherInstitute of Electrical and Electronics Engineers Inc.
    Pages832-837
    Number of pages6
    ISBN (Electronic)9781728146171
    DOIs
    Publication statusPublished - Oct 2019
    Event19th International Conference on Bioinformatics and Bioengineering, BIBE 2019 - Athens, Greece
    Duration: 28 Oct 201930 Oct 2019

    Publication series

    NameProceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019

    Conference

    Conference19th International Conference on Bioinformatics and Bioengineering, BIBE 2019
    Country/TerritoryGreece
    CityAthens
    Period28/10/1930/10/19

    Keywords

    • Huntington's disease
    • Metabolomics
    • PathwayConnector
    • Systems Bioinformatics

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