TY - JOUR
T1 - Continuous Maternal Glucose Infusion During Labor
T2 - Effects on Maternal and Fetal Glucose and Lactate Levels
AU - Nordström, L.
AU - Arulkumaran, S.
AU - Chua, S.
AU - Ratnam, S.
AU - Ingemarsson, I.
AU - Kublickas, M.
AU - Persson, B.
AU - Shimojo, N.
AU - Westgren, M.
PY - 1995
Y1 - 1995
N2 - Fetal and neonatal glucose and lactate levels and acid-base balance after continuous maternal infusion of 5% dextrose at 180 mL/h (9 g/h) was compared with 0.9% saline solution in a prospective, randomized study from selected monitored labors. An infusion of 5% dextrose produced significantly increased glucose levels in maternal (p < 0.01), cord artery (p < 0.01), and cord vein (p < 0.001) blood. An increased maternal insulin level was also present (p < 0.05), but no differences in cord insulin levels were observed. β-Hydroxybutyrate was lower in maternal (p < 0.05) and cord vein (p < 0.01), but not in cord artery blood, after maternal dextrose infusion. No significant changes occurred in blood lactate levels between the two groups in either mother, fetus, cord, or neonate. Acid-base balance in cord blood did not differ between the two groups. Maternal infusion of 5% dextrose at 180 mL/h (9 g/h), compared with saline solution, produces higher glucose levels in both mother and fetus, but increased insulin concentrations only in the mother. Dextrose infusion also lowers β-hydroxybutyrate in maternal and cord vein blood. No differences were seen in lactate levels or cord acid-base balance. Both regimens seem safe according to risks for lactacidosis and neonatal hypoglycemia in the normoxemic, normal size fetus.
AB - Fetal and neonatal glucose and lactate levels and acid-base balance after continuous maternal infusion of 5% dextrose at 180 mL/h (9 g/h) was compared with 0.9% saline solution in a prospective, randomized study from selected monitored labors. An infusion of 5% dextrose produced significantly increased glucose levels in maternal (p < 0.01), cord artery (p < 0.01), and cord vein (p < 0.001) blood. An increased maternal insulin level was also present (p < 0.05), but no differences in cord insulin levels were observed. β-Hydroxybutyrate was lower in maternal (p < 0.05) and cord vein (p < 0.01), but not in cord artery blood, after maternal dextrose infusion. No significant changes occurred in blood lactate levels between the two groups in either mother, fetus, cord, or neonate. Acid-base balance in cord blood did not differ between the two groups. Maternal infusion of 5% dextrose at 180 mL/h (9 g/h), compared with saline solution, produces higher glucose levels in both mother and fetus, but increased insulin concentrations only in the mother. Dextrose infusion also lowers β-hydroxybutyrate in maternal and cord vein blood. No differences were seen in lactate levels or cord acid-base balance. Both regimens seem safe according to risks for lactacidosis and neonatal hypoglycemia in the normoxemic, normal size fetus.
KW - acidosis
KW - fetal
KW - glucose
KW - glucose
KW - infusion
KW - lactate
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=0028838874&partnerID=8YFLogxK
U2 - 10.1055/s-2007-994496
DO - 10.1055/s-2007-994496
M3 - Article
C2 - 8540943
AN - SCOPUS:0028838874
SN - 0735-1631
VL - 12
SP - 357
EP - 362
JO - American Journal of Perinatology
JF - American Journal of Perinatology
IS - 5
ER -