Current therapies for chronic hepatitis B virus infection

Research output: Contribution to journalReview articlepeer-review


Patients who are chronically infected with the hepatitis B virus are at an increased risk of developing cirrhosis, hepatic decompensation and hepatocellular carcinoma. Therapeutic intervention offers the only means of interrupting this progression. Currently there are three licensed agents for the treatment of chronic hepatitis B virus infection. These are interferon-α, an immunomodulator, and two synthetic nucleos(t)ide analogs, namely lamivudine (Epivir®, GlaxoSmith Kline) and adefovir dipivoxil (Hepsera®, Gilead Sciences). This review aims to summarize current experience with these drugs in the treatment and management of patients with chronic hepatitis B virus infection, their efficacy, and current problems of drug resistance. An outline of future treatment perspectives is also included.

Original languageEnglish
Pages (from-to)745-760
Number of pages16
JournalExpert Review of Anti-Infective Therapy
Issue number5
Publication statusPublished - Oct 2004


  • Adefovir depivoxil
  • Antivirals
  • Hepatitis B virus
  • Interferon
  • Lamivudine
  • Nucleoside analog
  • Nucleotide analog
  • Treatment


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