Demographic changes of hepatitis B virus infection in Iran for the last two decades

Hamid Mohaghegh Shelmani, Peter Karayiannis, Sara Ashtari, Mohammad Amin Mahmanzar, Binazir Khanabadi, Niusha Modami, Fatemeh Gholipour, Fatemeh Zare, Mohammad Reza Zali

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Aim: The objective of this study was to evaluate the impact of the hepatitis B virus (HBV) vaccination program, 24 years after its implementation, by analyzing patients with hepatitis B surface antigen (HBsAg) infection based on gender and age group. Background: Since the launch of the first universal vaccination program against HBV in Iran in 1993, the epidemiological pattern of HBV prevalence may have changed in our country. Methods: All data for this cross-sectional study were collected from medical records of HBsAg positive patients, who were referred to the Golhak and Armin private laboratories and also to the Gastrointestinal Department of Tehran's Taleghani Hospital and Day Hospital in Iran over a period of 5 years (2011-2016). In total, 8,606 HBsAg positive subjects were assessed according to gender and age group. Results: The rates of HBsAg carriage were 0.8%, 7.8%, 49.3%, 27.9% and 14.1% among subjects under 14 years old, 15-24 years, 25-44 years, 45-59 years and those older than 60 years, respectively. According to the age subgroup analyses; the highest (26.2%) and lowest (0.6%) rate of HBsAg positivity was seen in the 31-40 age group and younger than 10 year old children, respectively. Conclusion: Global vaccination against hepatitis B has significantly reduced carrier rates among children and teenagers under 20 years old in this country. Nevertheless, HBsAg carriers still remain highly prevalent among 25-35-year age group. Therefore, the decline is limited to the younger population born after 1993, and it remains high in the middle-aged individuals.

    Original languageEnglish
    Pages (from-to)S38-S43
    JournalGastroenterology and Hepatology from Bed to Bench
    Volume10
    DOIs
    Publication statusPublished - 1 Jan 2017

    Fingerprint

    Virus Diseases
    Hepatitis B Surface Antigens
    Iran
    Hepatitis B virus
    Demography
    Age Groups
    Vaccination
    Armin
    Hepatitis B
    Medical Records
    Cross-Sectional Studies
    Infection
    Population

    Keywords

    • Epidemiology
    • Hepatitis B surface antigen (HBsAg)
    • Hepatitis B virus
    • Iran
    • Vaccination

    Cite this

    Shelmani, Hamid Mohaghegh ; Karayiannis, Peter ; Ashtari, Sara ; Mahmanzar, Mohammad Amin ; Khanabadi, Binazir ; Modami, Niusha ; Gholipour, Fatemeh ; Zare, Fatemeh ; Zali, Mohammad Reza. / Demographic changes of hepatitis B virus infection in Iran for the last two decades. In: Gastroenterology and Hepatology from Bed to Bench. 2017 ; Vol. 10. pp. S38-S43.
    @article{cc27d8b2825c4eb1ab7d2b67ee7a5643,
    title = "Demographic changes of hepatitis B virus infection in Iran for the last two decades",
    abstract = "Aim: The objective of this study was to evaluate the impact of the hepatitis B virus (HBV) vaccination program, 24 years after its implementation, by analyzing patients with hepatitis B surface antigen (HBsAg) infection based on gender and age group. Background: Since the launch of the first universal vaccination program against HBV in Iran in 1993, the epidemiological pattern of HBV prevalence may have changed in our country. Methods: All data for this cross-sectional study were collected from medical records of HBsAg positive patients, who were referred to the Golhak and Armin private laboratories and also to the Gastrointestinal Department of Tehran's Taleghani Hospital and Day Hospital in Iran over a period of 5 years (2011-2016). In total, 8,606 HBsAg positive subjects were assessed according to gender and age group. Results: The rates of HBsAg carriage were 0.8{\%}, 7.8{\%}, 49.3{\%}, 27.9{\%} and 14.1{\%} among subjects under 14 years old, 15-24 years, 25-44 years, 45-59 years and those older than 60 years, respectively. According to the age subgroup analyses; the highest (26.2{\%}) and lowest (0.6{\%}) rate of HBsAg positivity was seen in the 31-40 age group and younger than 10 year old children, respectively. Conclusion: Global vaccination against hepatitis B has significantly reduced carrier rates among children and teenagers under 20 years old in this country. Nevertheless, HBsAg carriers still remain highly prevalent among 25-35-year age group. Therefore, the decline is limited to the younger population born after 1993, and it remains high in the middle-aged individuals.",
    keywords = "Epidemiology, Hepatitis B surface antigen (HBsAg), Hepatitis B virus, Iran, Vaccination",
    author = "Shelmani, {Hamid Mohaghegh} and Peter Karayiannis and Sara Ashtari and Mahmanzar, {Mohammad Amin} and Binazir Khanabadi and Niusha Modami and Fatemeh Gholipour and Fatemeh Zare and Zali, {Mohammad Reza}",
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    doi = "10.22037/ghfbb.v0i0.1278",
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    Shelmani, HM, Karayiannis, P, Ashtari, S, Mahmanzar, MA, Khanabadi, B, Modami, N, Gholipour, F, Zare, F & Zali, MR 2017, 'Demographic changes of hepatitis B virus infection in Iran for the last two decades', Gastroenterology and Hepatology from Bed to Bench, vol. 10, pp. S38-S43. https://doi.org/10.22037/ghfbb.v0i0.1278

    Demographic changes of hepatitis B virus infection in Iran for the last two decades. / Shelmani, Hamid Mohaghegh; Karayiannis, Peter; Ashtari, Sara; Mahmanzar, Mohammad Amin; Khanabadi, Binazir; Modami, Niusha; Gholipour, Fatemeh; Zare, Fatemeh; Zali, Mohammad Reza.

    In: Gastroenterology and Hepatology from Bed to Bench, Vol. 10, 01.01.2017, p. S38-S43.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Demographic changes of hepatitis B virus infection in Iran for the last two decades

    AU - Shelmani, Hamid Mohaghegh

    AU - Karayiannis, Peter

    AU - Ashtari, Sara

    AU - Mahmanzar, Mohammad Amin

    AU - Khanabadi, Binazir

    AU - Modami, Niusha

    AU - Gholipour, Fatemeh

    AU - Zare, Fatemeh

    AU - Zali, Mohammad Reza

    PY - 2017/1/1

    Y1 - 2017/1/1

    N2 - Aim: The objective of this study was to evaluate the impact of the hepatitis B virus (HBV) vaccination program, 24 years after its implementation, by analyzing patients with hepatitis B surface antigen (HBsAg) infection based on gender and age group. Background: Since the launch of the first universal vaccination program against HBV in Iran in 1993, the epidemiological pattern of HBV prevalence may have changed in our country. Methods: All data for this cross-sectional study were collected from medical records of HBsAg positive patients, who were referred to the Golhak and Armin private laboratories and also to the Gastrointestinal Department of Tehran's Taleghani Hospital and Day Hospital in Iran over a period of 5 years (2011-2016). In total, 8,606 HBsAg positive subjects were assessed according to gender and age group. Results: The rates of HBsAg carriage were 0.8%, 7.8%, 49.3%, 27.9% and 14.1% among subjects under 14 years old, 15-24 years, 25-44 years, 45-59 years and those older than 60 years, respectively. According to the age subgroup analyses; the highest (26.2%) and lowest (0.6%) rate of HBsAg positivity was seen in the 31-40 age group and younger than 10 year old children, respectively. Conclusion: Global vaccination against hepatitis B has significantly reduced carrier rates among children and teenagers under 20 years old in this country. Nevertheless, HBsAg carriers still remain highly prevalent among 25-35-year age group. Therefore, the decline is limited to the younger population born after 1993, and it remains high in the middle-aged individuals.

    AB - Aim: The objective of this study was to evaluate the impact of the hepatitis B virus (HBV) vaccination program, 24 years after its implementation, by analyzing patients with hepatitis B surface antigen (HBsAg) infection based on gender and age group. Background: Since the launch of the first universal vaccination program against HBV in Iran in 1993, the epidemiological pattern of HBV prevalence may have changed in our country. Methods: All data for this cross-sectional study were collected from medical records of HBsAg positive patients, who were referred to the Golhak and Armin private laboratories and also to the Gastrointestinal Department of Tehran's Taleghani Hospital and Day Hospital in Iran over a period of 5 years (2011-2016). In total, 8,606 HBsAg positive subjects were assessed according to gender and age group. Results: The rates of HBsAg carriage were 0.8%, 7.8%, 49.3%, 27.9% and 14.1% among subjects under 14 years old, 15-24 years, 25-44 years, 45-59 years and those older than 60 years, respectively. According to the age subgroup analyses; the highest (26.2%) and lowest (0.6%) rate of HBsAg positivity was seen in the 31-40 age group and younger than 10 year old children, respectively. Conclusion: Global vaccination against hepatitis B has significantly reduced carrier rates among children and teenagers under 20 years old in this country. Nevertheless, HBsAg carriers still remain highly prevalent among 25-35-year age group. Therefore, the decline is limited to the younger population born after 1993, and it remains high in the middle-aged individuals.

    KW - Epidemiology

    KW - Hepatitis B surface antigen (HBsAg)

    KW - Hepatitis B virus

    KW - Iran

    KW - Vaccination

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    U2 - 10.22037/ghfbb.v0i0.1278

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    M3 - Article

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