Detection of serum HBV-DNA by molecular hybridisation. Correlation with HBeAg/anti-HBe status, racial origin, liver histology and hepatocellular carcinoma

Peter Karayiannis, Martin J F Fowler, Anna S F Lok, Charlie Greenfield, Jon Monjardino, Howard C. Thomas

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The relationship of the presence of hepatitis B virus (HBV) DNA in serum, a measure of HBV-replication, to HBeAg/anti-HBe status has been examined. In Northern Europe, there is a strong positive correlation between the presence of HBV-DNA and HBe antigenaemia and a negative correlation with the presence of anti-HBe. These associations are less marked in patients from Southern Europe, Africa, the Middle and Far East. When HBV-DNA is present in the serum of anti-HBe carriers, it is usually associated with the presence of severe liver disease or carcinoma. Forty percent of patients with hepatocellular carcinoma had evidence of continuing HBV replication.

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalJournal of Hepatology
Volume1
Issue number2
DOIs
Publication statusPublished - 1985

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