TY - JOUR
T1 - Detection of serum HBV-DNA by molecular hybridisation. Correlation with HBeAg/anti-HBe status, racial origin, liver histology and hepatocellular carcinoma
AU - Karayiannis, Peter
AU - Fowler, Martin J F
AU - Lok, Anna S F
AU - Greenfield, Charlie
AU - Monjardino, Jon
AU - Thomas, Howard C.
PY - 1985
Y1 - 1985
N2 - The relationship of the presence of hepatitis B virus (HBV) DNA in serum, a measure of HBV-replication, to HBeAg/anti-HBe status has been examined. In Northern Europe, there is a strong positive correlation between the presence of HBV-DNA and HBe antigenaemia and a negative correlation with the presence of anti-HBe. These associations are less marked in patients from Southern Europe, Africa, the Middle and Far East. When HBV-DNA is present in the serum of anti-HBe carriers, it is usually associated with the presence of severe liver disease or carcinoma. Forty percent of patients with hepatocellular carcinoma had evidence of continuing HBV replication.
AB - The relationship of the presence of hepatitis B virus (HBV) DNA in serum, a measure of HBV-replication, to HBeAg/anti-HBe status has been examined. In Northern Europe, there is a strong positive correlation between the presence of HBV-DNA and HBe antigenaemia and a negative correlation with the presence of anti-HBe. These associations are less marked in patients from Southern Europe, Africa, the Middle and Far East. When HBV-DNA is present in the serum of anti-HBe carriers, it is usually associated with the presence of severe liver disease or carcinoma. Forty percent of patients with hepatocellular carcinoma had evidence of continuing HBV replication.
UR - http://www.scopus.com/inward/record.url?scp=84886641026&partnerID=8YFLogxK
U2 - 10.1016/S0168-8278(85)80758-3
DO - 10.1016/S0168-8278(85)80758-3
M3 - Article
C2 - 2997321
AN - SCOPUS:84886641026
SN - 0168-8278
VL - 1
SP - 99
EP - 106
JO - Journal of Hepatology
JF - Journal of Hepatology
IS - 2
ER -