Detection of serum HBV-DNA by molecular hybridisation. Correlation with HBeAg/anti-HBe status, racial origin, liver histology and hepatocellular carcinoma

Peter Karayiannis; Martin J F Fowler; Anna S F Lok; Charlie Greenfield; Jon Monjardino; Howard C. Thomas

doi:10.1016/S0168-8278(85)80758-3

Detection of serum HBV-DNA by molecular hybridisation. Correlation with HBeAg/anti-HBe status, racial origin, liver histology and hepatocellular carcinoma

Peter Karayiannis
, Martin J F Fowler
, Anna S F Lok
, Charlie Greenfield
, Jon Monjardino
, Howard C. Thomas

Medical School

University College London

Research output: Contribution to journal › Article › peer-review

Abstract

The relationship of the presence of hepatitis B virus (HBV) DNA in serum, a measure of HBV-replication, to HBeAg/anti-HBe status has been examined. In Northern Europe, there is a strong positive correlation between the presence of HBV-DNA and HBe antigenaemia and a negative correlation with the presence of anti-HBe. These associations are less marked in patients from Southern Europe, Africa, the Middle and Far East. When HBV-DNA is present in the serum of anti-HBe carriers, it is usually associated with the presence of severe liver disease or carcinoma. Forty percent of patients with hepatocellular carcinoma had evidence of continuing HBV replication.

Original language	English
Pages (from-to)	99-106
Number of pages	8
Journal	Journal of Hepatology
Volume	1
Issue number	2
DOIs	https://doi.org/10.1016/S0168-8278(85)80758-3
Publication status	Published - 1985

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10.1016/S0168-8278(85)80758-3

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title = "Detection of serum HBV-DNA by molecular hybridisation. Correlation with HBeAg/anti-HBe status, racial origin, liver histology and hepatocellular carcinoma",

abstract = "The relationship of the presence of hepatitis B virus (HBV) DNA in serum, a measure of HBV-replication, to HBeAg/anti-HBe status has been examined. In Northern Europe, there is a strong positive correlation between the presence of HBV-DNA and HBe antigenaemia and a negative correlation with the presence of anti-HBe. These associations are less marked in patients from Southern Europe, Africa, the Middle and Far East. When HBV-DNA is present in the serum of anti-HBe carriers, it is usually associated with the presence of severe liver disease or carcinoma. Forty percent of patients with hepatocellular carcinoma had evidence of continuing HBV replication.",

author = "Peter Karayiannis and Fowler, \{Martin J F\} and Lok, \{Anna S F\} and Charlie Greenfield and Jon Monjardino and Thomas, \{Howard C.\}",

year = "1985",

doi = "10.1016/S0168-8278(85)80758-3",

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pages = "99--106",

journal = "Journal of Hepatology",

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T1 - Detection of serum HBV-DNA by molecular hybridisation. Correlation with HBeAg/anti-HBe status, racial origin, liver histology and hepatocellular carcinoma

AU - Karayiannis, Peter

AU - Fowler, Martin J F

AU - Lok, Anna S F

AU - Greenfield, Charlie

AU - Monjardino, Jon

AU - Thomas, Howard C.

PY - 1985

Y1 - 1985

N2 - The relationship of the presence of hepatitis B virus (HBV) DNA in serum, a measure of HBV-replication, to HBeAg/anti-HBe status has been examined. In Northern Europe, there is a strong positive correlation between the presence of HBV-DNA and HBe antigenaemia and a negative correlation with the presence of anti-HBe. These associations are less marked in patients from Southern Europe, Africa, the Middle and Far East. When HBV-DNA is present in the serum of anti-HBe carriers, it is usually associated with the presence of severe liver disease or carcinoma. Forty percent of patients with hepatocellular carcinoma had evidence of continuing HBV replication.

AB - The relationship of the presence of hepatitis B virus (HBV) DNA in serum, a measure of HBV-replication, to HBeAg/anti-HBe status has been examined. In Northern Europe, there is a strong positive correlation between the presence of HBV-DNA and HBe antigenaemia and a negative correlation with the presence of anti-HBe. These associations are less marked in patients from Southern Europe, Africa, the Middle and Far East. When HBV-DNA is present in the serum of anti-HBe carriers, it is usually associated with the presence of severe liver disease or carcinoma. Forty percent of patients with hepatocellular carcinoma had evidence of continuing HBV replication.

UR - https://www.scopus.com/pages/publications/84886641026

U2 - 10.1016/S0168-8278(85)80758-3

DO - 10.1016/S0168-8278(85)80758-3

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AN - SCOPUS:84886641026

SN - 0168-8278

VL - 1

SP - 99

EP - 106

JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 2

ER -

Detection of serum HBV-DNA by molecular hybridisation. Correlation with HBeAg/anti-HBe status, racial origin, liver histology and hepatocellular carcinoma

Abstract

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