Development of hepatic pathology in GBV-B-infected red-bellied tamarins (Saguinus labiatus)

Jessica M. Dale, Simon P. Hood, Ori Bowen, Helen Bright, Keith L. Cutler, Neil Berry, Neil Almond, Robert Goldin, Peter Karayiannis, Nicola J. Rose

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    Abstract

    GB virus B (GBV-B) is a new world monkey-associated flavivirus used to model acute hepatitis C virus (HCV) infection. Critical for evaluation of antiviral or vaccine approaches is an understanding of the effect of HCV on the liver at different stages of infection. In the absence of longitudinal human tissue samples at defined time points, we have characterized changes in tamarins. As early as 2 weeks post-infection histological changes were noticeable, and these were established in all animals by 6 weeks. Despite high levels of liver-associated viral RNA, there was reversal of hepatic damage on clearance of peripheral virus though fibrosis was demonstrated in four tamarins. Notably, viral RNA burden in the liver dropped to near undetectable or background levels in all animals which underwent a second viral challenge, highlighting the efficacy of the immune response in removing foci of replication in the liver. These data add to the knowledge of GBV-B infection in New World primates which can offer attractive systems for the testing of prophylactic and therapeutic treatments and the evaluation of their utility in preventing or reversing liver pathology.

    Original languageEnglish
    JournalJournal of Medical Virology
    DOIs
    Publication statusAccepted/In press - 1 Jan 2020

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    Keywords

    • animal models of infection
    • hepatitis virus
    • local infection
    • replication
    • spread

    Cite this

    Dale, J. M., Hood, S. P., Bowen, O., Bright, H., Cutler, K. L., Berry, N., Almond, N., Goldin, R., Karayiannis, P., & Rose, N. J. (Accepted/In press). Development of hepatic pathology in GBV-B-infected red-bellied tamarins (Saguinus labiatus). Journal of Medical Virology. https://doi.org/10.1002/jmv.25769