Dietary protein restriction reduces the frequency and delays the onset of insulin dependent diabetes in BB rats

Mark A. Atkinson, William E. Winter, Nicos Skordis, Hidehiro Beppu, William M. Riley, Noel K. Maclaren

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Environmental agents have been implicated in the pathogenesis of insulin dependent diabetes (IDD). These studies were designed to learn if dietary protein influences the development of IDD in the BB rat. Specifically, analysis involved the effects of substituting a modified, semi-synthetic diet (AIN-76) containing soy protein as the sole protein source for the standard chow containing a mixture of animal and non-animal protein. IDD was less frequent (73% vs. 38%, P ≤ 0.01), and the onset of diabetes was retarded (110 ± 11.0 vs. 92 ± 15.5 days, P ≤ 0.01) in rats fed the study diet versus standard chow, respectively. The frequency of thyroid collodal autoantibodies was also significantly decreased in rats fed the study diet (56% vs. 23%, P ≤ 0.04), whereas frequencies of smooth muscle and gastric parietal cell autoantibodies were less frequent, but not significantly so. Lymphocyte counts and subsets were unaffected. In non-diabetic rats at greater than 180 days of age, insulitis was less severe in the experimental group. These findings suggested that dietary protein may influence the development of IDD in the BB rat.

Original languageEnglish
Pages (from-to)11-19
Number of pages9
JournalAutoimmunity
Volume2
Issue number1
DOIs
Publication statusPublished - 1988

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Inbred BB Rats
Dietary Proteins
Insulin
Autoantibodies
Gastric Parietal Cells
Diet
Formulated Food
Soybean Proteins
Lymphocyte Subsets
Lymphocyte Count
Smooth Muscle
Thyroid Gland
Proteins

Keywords

  • Autoimmunity
  • BB rat
  • Diet
  • Insulin-dependent diabetes

Cite this

Atkinson, M. A., Winter, W. E., Skordis, N., Beppu, H., Riley, W. M., & Maclaren, N. K. (1988). Dietary protein restriction reduces the frequency and delays the onset of insulin dependent diabetes in BB rats. Autoimmunity, 2(1), 11-19. https://doi.org/10.3109/08916938809019939
Atkinson, Mark A. ; Winter, William E. ; Skordis, Nicos ; Beppu, Hidehiro ; Riley, William M. ; Maclaren, Noel K. / Dietary protein restriction reduces the frequency and delays the onset of insulin dependent diabetes in BB rats. In: Autoimmunity. 1988 ; Vol. 2, No. 1. pp. 11-19.
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Atkinson, MA, Winter, WE, Skordis, N, Beppu, H, Riley, WM & Maclaren, NK 1988, 'Dietary protein restriction reduces the frequency and delays the onset of insulin dependent diabetes in BB rats', Autoimmunity, vol. 2, no. 1, pp. 11-19. https://doi.org/10.3109/08916938809019939

Dietary protein restriction reduces the frequency and delays the onset of insulin dependent diabetes in BB rats. / Atkinson, Mark A.; Winter, William E.; Skordis, Nicos; Beppu, Hidehiro; Riley, William M.; Maclaren, Noel K.

In: Autoimmunity, Vol. 2, No. 1, 1988, p. 11-19.

Research output: Contribution to journalArticle

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