TY - JOUR
T1 - Differential dose-dependent effects of central morphine treatment upon food intake in male and female rats receiving neonatal hormone manipulations
AU - Bodnar, Richard J.
AU - Hadjimarkou, Maria M.
AU - Krzanowska, Eliza K.
AU - Silva, Robert M.
AU - Stein, June A.
PY - 2003/2
Y1 - 2003/2
N2 - Male rats display significantly greater analgesic responses following morphine than female rats, with neonatal gonadal manipulations reversing the sex-dependent pattern. The present study assessed whether dose-dependent (0.0005-5 μg, icv) effects of morphine-induced feeding were sensitive to sex-dependent and neonatal gonadectomy manipulations. Sex differences in morphine-induced feeding varied as a function of morphine dose with males showing greater increases at low (0.0005 μg) doses, and females showing greater increases at high (5 μg) doses. Neonatal castration, respectively, enhanced and reduced morphine-induced feeding at very low (0.0005 μg) and low (0.005 μg) doses. In contrast, neonatal testosterone administered to females enhanced morphine-induced feeding at higher (0.5-5 μg) doses. These data indicate that sex and neonatal gonadectomy differences in morphine-induced feeding are dependent upon the dose of morphine employed.
AB - Male rats display significantly greater analgesic responses following morphine than female rats, with neonatal gonadal manipulations reversing the sex-dependent pattern. The present study assessed whether dose-dependent (0.0005-5 μg, icv) effects of morphine-induced feeding were sensitive to sex-dependent and neonatal gonadectomy manipulations. Sex differences in morphine-induced feeding varied as a function of morphine dose with males showing greater increases at low (0.0005 μg) doses, and females showing greater increases at high (5 μg) doses. Neonatal castration, respectively, enhanced and reduced morphine-induced feeding at very low (0.0005 μg) and low (0.005 μg) doses. In contrast, neonatal testosterone administered to females enhanced morphine-induced feeding at higher (0.5-5 μg) doses. These data indicate that sex and neonatal gonadectomy differences in morphine-induced feeding are dependent upon the dose of morphine employed.
KW - Feeding
KW - Morphine
KW - Neonatal gonadectomy
KW - Sex differences
UR - http://www.scopus.com/inward/record.url?scp=0037310869&partnerID=8YFLogxK
U2 - 10.1080/1028415021000042848
DO - 10.1080/1028415021000042848
M3 - Article
C2 - 12608737
AN - SCOPUS:0037310869
SN - 1028-415X
VL - 6
SP - 53
EP - 57
JO - Nutritional Neuroscience
JF - Nutritional Neuroscience
IS - 1
ER -