Do we miss rare adverse events induced by COVID-19 vaccination?

Zeinab Mohseni Afshar, Ali Tavakoli Pirzaman, Jackson J. Liang, Akanksha Sharma, Marzieh Pirzadeh, Arefeh Babazadeh, Erfan Hashemi, Niloofar Deravi, Sadaf Abdi, Amirreza Allahgholipour, Rezvan Hosseinzadeh, Zahra Vaziri, Terence T. Sio, Mark J.M. Sullman, Mohammad Barary, Soheil Ebrahimpour

Research output: Contribution to journalReview articlepeer-review


Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has caused many complications, the invention of coronavirus disease 2019 (COVID-19) vaccines has also brought about several adverse events, from common side effects to unexpected and rare ones. Common vaccine-related adverse reactions manifest locally or systematically following any vaccine, including COVID-19 vaccines. Specific side effects, known as adverse events of particular interest (AESI), are unusual and need more evaluation. Here, we discuss some of the most critical rare adverse events of COVID-19 vaccines.

Original languageEnglish
Article number933914
JournalFrontiers in Medicine
Publication statusPublished - 10 Oct 2022


  • COVID-19
  • drug-related side effects and adverse reactions
  • pandemic (COVID-19)
  • SARS-CoV-2
  • vaccination


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