TY - JOUR
T1 - Does the route of administration of misoprostol make a difference? The uterotonic effect and side effects of misoprostol given by different routes after vaginal delivery
AU - Chong, Yap Seng
AU - Chua, Selina
AU - Shen, Liang
AU - Arulkumaran, Sabaratnam
PY - 2004/4/15
Y1 - 2004/4/15
N2 - Objective: To compare the postpartum uterotonic effect and side effects of misoprostol administered by different routes. Study design: Fifty women were given misoprostol 400μg either by the oral solution, oral tablet, rectal or vaginal route, or intramuscular syntometrine 1ml after spontaneous vaginal delivery. Pre- and post-treatment uterine activity were measured with intrauterine pressure catheters. Results: Uterine activity produced by oral solution misoprostol 400μg was significantly higher than that of oral tablet, rectal and vaginal misoprostol (P=0.045, 0.004, 0.002, respectively). Onset of action after oral solution misoprostol was faster than by the oral tablet (P=0.01), rectal (P<0.001) and vaginal (P<0.001) routes. Shivering and pyrexia were most common with oral solution misoprostol. Maximum body temperature recorded was significantly higher with oral solution misoprostol than with oral tablet, rectal and vaginal misoprostol (P=0.005, 0.009, 0.001, respectively). Conclusion: Different routes of administering misoprostol greatly influence the effects achieved. Oral solution misoprostol produces the fastest and strongest uterotonic effect, with the most side effects.
AB - Objective: To compare the postpartum uterotonic effect and side effects of misoprostol administered by different routes. Study design: Fifty women were given misoprostol 400μg either by the oral solution, oral tablet, rectal or vaginal route, or intramuscular syntometrine 1ml after spontaneous vaginal delivery. Pre- and post-treatment uterine activity were measured with intrauterine pressure catheters. Results: Uterine activity produced by oral solution misoprostol 400μg was significantly higher than that of oral tablet, rectal and vaginal misoprostol (P=0.045, 0.004, 0.002, respectively). Onset of action after oral solution misoprostol was faster than by the oral tablet (P=0.01), rectal (P<0.001) and vaginal (P<0.001) routes. Shivering and pyrexia were most common with oral solution misoprostol. Maximum body temperature recorded was significantly higher with oral solution misoprostol than with oral tablet, rectal and vaginal misoprostol (P=0.005, 0.009, 0.001, respectively). Conclusion: Different routes of administering misoprostol greatly influence the effects achieved. Oral solution misoprostol produces the fastest and strongest uterotonic effect, with the most side effects.
KW - Misoprostol
KW - Postpartum haemorrhage
KW - Route of administration
KW - Side effects
KW - Uterotonic
UR - http://www.scopus.com/inward/record.url?scp=1842506721&partnerID=8YFLogxK
U2 - 10.1016/j.ejogrb.2003.09.011
DO - 10.1016/j.ejogrb.2003.09.011
M3 - Article
C2 - 15063959
AN - SCOPUS:1842506721
SN - 0301-2115
VL - 113
SP - 191
EP - 198
JO - European Journal of Obstetrics Gynecology and Reproductive Biology
JF - European Journal of Obstetrics Gynecology and Reproductive Biology
IS - 2
ER -