Don't go breaking my heart valve: Historical review of mitral valve replacement

Constantinos Zervides, Samantha Verran, Prusothman Yoganantharajah, Kassem K. Sifeldeen

    Research output: Contribution to journalReview articlepeer-review


    Management of mitral valve disease in the western world continues to lag behind its aortic counterpart, particularly in the realm of percutaneous valve replacement. It is a more complex anatomical region, with varying disease states and unique pathophysiological and epidemiological characteristics that make it a distinct challenge to treat in modern medicine. Latest research and development, however, have provided new answers to the challenges associated with the mitral valve. In this review, the most common disease states afflicting the mitral valve are outlined, specific challenges associated with treatment are discussed, and both current and cutting-edge replacement devices are described. This review focuses on replacement and prosthetic devices, while acknowledging the role of valve repair. The future of mitral valve replacement remains to be seen, as new methodologies and prosthetic designs continue to present themselves as the best answer to the challenge.

    Original languageEnglish
    Pages (from-to)899-915
    Number of pages17
    JournalFuture Cardiology
    Issue number5
    Publication statusPublished - Aug 2021


    • mitral regurgitation (MR)
    • mitral valve prolapse (MVP)
    • percutaneous mitral valve implant (PMVI)
    • transcatheter aortic valve replacement (TAVR)
    • transcatheter mitral valve repair (TMVr)
    • transcatheter mitral valve replacement (TMVR)


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