Effects of 12 months of detraining on health-related quality of life in patients receiving hemodialysis therapy

Clara Suemi Costa Rosa, Christoforos D. Giannaki, Argyro Krase, Meropi Mplekou, Stefania S. Grigoriou, Ioannis Stefanidis, Eleftherios Lavdas, Aggelos Pappas, Saul Bloxham, Christina Karatzaferi, Giorgos K. Sakkas

Research output: Contribution to journalArticlepeer-review


Purpose: Limited data exist regarding the effects of detraining on functional capacity and quality of life (QoL) in the hemodialysis population. The aim of the current study was to assess whether the discontinuation from a systematic intradialytic exercise training program will affect aspects of health-related QoL and functional capacity in hemodialysis patients. Methods: Seventeen hemodialysis patients (12 Males/5 Females, age 60.8 ± 13.6 year) participated in this study. Patients were assessed for functional capacity using various functional capacity tests while QoL, daily sleepiness, sleep quality, depression and fatigue were assessed using validated questionnaires at the end of a 12-month aerobic exercise program and after 12 months of detraining. Results: The detraining significantly reduced patients’ QoL score by 20% (P = 0.01). More affected were aspects related to the physical component summary of the QoL (P < 0.001) rather than those related to the mental one (P = 0.096). In addition, the performance in the functional capacity tests was reduced (P < 0.05), while sleep quality (P = 0.020) and daily sleepiness scores (P = 0.006) were significantly worse after the detraining period. Depressive symptoms (P = 0.214) and the level of fatigue (P = 0.163) did not change significantly. Conclusions: Detraining has a detrimental effect in patients’ QoL, functional capacity and sleep quality. The affected physical health contributed significantly to the lower QoL score. It is crucial for the chronic disease patients, even during emergencies such as lockdowns and restrictions in activities to maintain a minimum level of activity to preserve some of the acquired benefits and maintain their health status.

Original languageEnglish
Pages (from-to)1771-1778
Number of pages8
JournalInternational Urology and Nephrology
Issue number9
Publication statusPublished - 1 Sept 2020


  • Detraining
  • Exercise training
  • Hemodialysis
  • Quality of life


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