Effects of debrisoquin and haloperidol on plasma homovanillic acid concentration in schizophrenic patients

Michael Davidson; Miklos F. Losonczy; Richard C. Mohs; Juliet C. Lesser; Peter Powchik; Linda B. Freed; Bonnie M. Davis; Victoria V. Mykytyn; Kenneth L. Davis

doi:10.1016/0893-133X(87)90005-4

Effects of debrisoquin and haloperidol on plasma homovanillic acid concentration in schizophrenic patients

Michael Davidson
, Miklos F. Losonczy
, Richard C. Mohs
, Juliet C. Lesser
, Peter Powchik
, Linda B. Freed
, Bonnie M. Davis
, Victoria V. Mykytyn
, Kenneth L. Davis

Bronx Veterans Association Medical Center

Research output: Contribution to journal › Article › peer-review

Abstract

Plasma levels of the dopamine metabolite homovanillic acid (pHVA) may potentially reflect upon central dopamine activity. This study examines the effects of debrisoquin, haloperidol, and the two drugs combined on pHVA concentrations of schizophrenic patients. Debrisoquin is a drug that suppresses the peripheral formation of homovanillic acid without affecting the central formation. Acute haloperidol administration consistently increased pHVA concentrations in patients pretreated or not pretreated with debrisoquin, suggesting that this increment reflects haloperidol's central and not peripheral effects.

Original language	English
Pages (from-to)	17-23
Number of pages	7
Journal	Neuropsychopharmacology
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/0893-133X(87)90005-4
Publication status	Published - Dec 1987
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Debrisoquin
Haloperidol
Homovanillic acid
Schizophrenia

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10.1016/0893-133X(87)90005-4

Cite this

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title = "Effects of debrisoquin and haloperidol on plasma homovanillic acid concentration in schizophrenic patients",

abstract = "Plasma levels of the dopamine metabolite homovanillic acid (pHVA) may potentially reflect upon central dopamine activity. This study examines the effects of debrisoquin, haloperidol, and the two drugs combined on pHVA concentrations of schizophrenic patients. Debrisoquin is a drug that suppresses the peripheral formation of homovanillic acid without affecting the central formation. Acute haloperidol administration consistently increased pHVA concentrations in patients pretreated or not pretreated with debrisoquin, suggesting that this increment reflects haloperidol's central and not peripheral effects.",

keywords = "Debrisoquin, Haloperidol, Homovanillic acid, Schizophrenia",

author = "Michael Davidson and Losonczy, \{Miklos F.\} and Mohs, \{Richard C.\} and Lesser, \{Juliet C.\} and Peter Powchik and Freed, \{Linda B.\} and Davis, \{Bonnie M.\} and Mykytyn, \{Victoria V.\} and Davis, \{Kenneth L.\}",

year = "1987",

month = dec,

doi = "10.1016/0893-133X(87)90005-4",

language = "English",

volume = "1",

pages = "17--23",

journal = "Neuropsychopharmacology",

issn = "0893-133X",

publisher = "Springer Nature",

number = "1",

}

TY - JOUR

T1 - Effects of debrisoquin and haloperidol on plasma homovanillic acid concentration in schizophrenic patients

AU - Davidson, Michael

AU - Losonczy, Miklos F.

AU - Mohs, Richard C.

AU - Lesser, Juliet C.

AU - Powchik, Peter

AU - Freed, Linda B.

AU - Davis, Bonnie M.

AU - Mykytyn, Victoria V.

AU - Davis, Kenneth L.

PY - 1987/12

Y1 - 1987/12

N2 - Plasma levels of the dopamine metabolite homovanillic acid (pHVA) may potentially reflect upon central dopamine activity. This study examines the effects of debrisoquin, haloperidol, and the two drugs combined on pHVA concentrations of schizophrenic patients. Debrisoquin is a drug that suppresses the peripheral formation of homovanillic acid without affecting the central formation. Acute haloperidol administration consistently increased pHVA concentrations in patients pretreated or not pretreated with debrisoquin, suggesting that this increment reflects haloperidol's central and not peripheral effects.

AB - Plasma levels of the dopamine metabolite homovanillic acid (pHVA) may potentially reflect upon central dopamine activity. This study examines the effects of debrisoquin, haloperidol, and the two drugs combined on pHVA concentrations of schizophrenic patients. Debrisoquin is a drug that suppresses the peripheral formation of homovanillic acid without affecting the central formation. Acute haloperidol administration consistently increased pHVA concentrations in patients pretreated or not pretreated with debrisoquin, suggesting that this increment reflects haloperidol's central and not peripheral effects.

KW - Debrisoquin

KW - Haloperidol

KW - Homovanillic acid

KW - Schizophrenia

UR - https://www.scopus.com/pages/publications/0023561275

U2 - 10.1016/0893-133X(87)90005-4

DO - 10.1016/0893-133X(87)90005-4

M3 - Article

C2 - 3509064

AN - SCOPUS:0023561275

SN - 0893-133X

VL - 1

SP - 17

EP - 23

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

IS - 1

ER -

Effects of debrisoquin and haloperidol on plasma homovanillic acid concentration in schizophrenic patients

Abstract

UN SDGs

Keywords

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