TY - JOUR
T1 - Effects of isradipine, a new calcium antagonist, on maternal cardiovascular system and uterine activity in labour
AU - WIDE‐SWENSSON, D.
AU - TNGEMARSSON, T.
AU - ARULKUMARAN, S.
AU - ANDERSSON, K. ‐E
PY - 1990
Y1 - 1990
N2 - Summary. The effects of isradipine (a new calcium antagonist of the dihydropyridine type) on maternal blood pressure and heart rate, fetal heart rate, and uterine activity in labour were measured. Uterine activity was recorded by an intrauterine microtip transducer catheter connected to a fetal monitor. Isradipine was given as a slow injection in doses of 0.5 mg (10 women), 1 mg (11 women), and 1.5 mg (6 women). A reduction of systolic (6–16%) and diastolic (19‐22%) blood pressure was seen, and concomitantly there was an increase in maternal (29–34%) and fetal (3–10%) heart rates. Reduction in uterine activity was not dose‐related (maximum reduction 17%). Side effects (headache, palpitations) were minor and well tolerated. One woman in the highdose group had a shortlasting episode of hypotension. The results suggest that isradipine given as a bolus dose decreases blood pressure in pregnant women with little effects on uterine activity and fetal heart rate.
AB - Summary. The effects of isradipine (a new calcium antagonist of the dihydropyridine type) on maternal blood pressure and heart rate, fetal heart rate, and uterine activity in labour were measured. Uterine activity was recorded by an intrauterine microtip transducer catheter connected to a fetal monitor. Isradipine was given as a slow injection in doses of 0.5 mg (10 women), 1 mg (11 women), and 1.5 mg (6 women). A reduction of systolic (6–16%) and diastolic (19‐22%) blood pressure was seen, and concomitantly there was an increase in maternal (29–34%) and fetal (3–10%) heart rates. Reduction in uterine activity was not dose‐related (maximum reduction 17%). Side effects (headache, palpitations) were minor and well tolerated. One woman in the highdose group had a shortlasting episode of hypotension. The results suggest that isradipine given as a bolus dose decreases blood pressure in pregnant women with little effects on uterine activity and fetal heart rate.
UR - http://www.scopus.com/inward/record.url?scp=0025059336&partnerID=8YFLogxK
U2 - 10.1111/j.1471-0528.1990.tb02452.x
DO - 10.1111/j.1471-0528.1990.tb02452.x
M3 - Article
C2 - 2145969
AN - SCOPUS:0025059336
SN - 1470-0328
VL - 97
SP - 945
EP - 949
JO - BJOG: An International Journal of Obstetrics & Gynaecology
JF - BJOG: An International Journal of Obstetrics & Gynaecology
IS - 10
ER -