Abstract
For -omics investigations to achieve their aspired potential, fundamental aspects relating to the study design and statistical analyses in clinical -omics investigations must be dully addressed. The present chapter addresses the most appropriate epidemiological study designs for assessing diagnostic and prognostic biomarkers including cross-sectional, case-control, and cohort studies. Modes of their optimal implementation, as well as potential pitfalls, are detailed. Finally, statistical approaches for evaluating the utility of diagnostic and prognostic biomarkers are also discussed.
| Original language | English |
|---|---|
| Title of host publication | Integration of Omics Approaches and Systems Biology for Clinical Applications |
| Publisher | wiley |
| Pages | 207-214 |
| Number of pages | 8 |
| ISBN (Electronic) | 9781119183952 |
| ISBN (Print) | 9781119181149 |
| DOIs | |
| Publication status | Published - 17 Nov 2017 |
| Externally published | Yes |
Keywords
- Biostatistics
- Epidemiologic methods
- Epidemiologic research design
- Evidence-level grading
- Molecular epidemiology
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