Evidence for 5-hydroxytryptamine1A receptor involvement in the control of prolactin secretion in man

E. Palazidou; J. Stephenson; J. Butler; P. Coskeran; S. Chambers; A. M. McGregor

doi:10.1007/BF02246297

Evidence for 5-hydroxytryptamine_1A receptor involvement in the control of prolactin secretion in man

E. Palazidou, J. Stephenson, J. Butler, P. Coskeran, S. Chambers, A. M. McGregor

Medical School

King's College London

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of pindolol pretreatment (2 days) on prolactin and cortisol responses to a single dose of (+)-fenfluramine (30 mg po) were examined in nine healthy male volunteers. Pindolol pretreatment attenuated the (+)-fenfluramine-induced increase in prolactin concentrations but failed to affect the (+)-fenfluramine-induced cortisol increase. These data provide evidence in support of 5-HT1A receptor involvement in the regulation of prolactin secretion but question its importance in the regulation of cortisol secretion in man

Original language	English
Pages (from-to)	311-314
Number of pages	4
Journal	Psychopharmacology
Volume	119
Issue number	3
DOIs	https://doi.org/10.1007/BF02246297
Publication status	Published - Jun 1995

Keywords

5-HT receptors
Cortisol
Fenfluramine
Man
Pindolol
Prolactin

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10.1007/BF02246297

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title = "Evidence for 5-hydroxytryptamine1A receptor involvement in the control of prolactin secretion in man",

abstract = "The effects of pindolol pretreatment (2 days) on prolactin and cortisol responses to a single dose of (+)-fenfluramine (30 mg po) were examined in nine healthy male volunteers. Pindolol pretreatment attenuated the (+)-fenfluramine-induced increase in prolactin concentrations but failed to affect the (+)-fenfluramine-induced cortisol increase. These data provide evidence in support of 5-HT1A receptor involvement in the regulation of prolactin secretion but question its importance in the regulation of cortisol secretion in man",

keywords = "5-HT receptors, Cortisol, Fenfluramine, Man, Pindolol, Prolactin",

author = "E. Palazidou and J. Stephenson and J. Butler and P. Coskeran and S. Chambers and McGregor, {A. M.}",

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T1 - Evidence for 5-hydroxytryptamine1A receptor involvement in the control of prolactin secretion in man

AU - Palazidou, E.

AU - Stephenson, J.

AU - Butler, J.

AU - Coskeran, P.

AU - Chambers, S.

AU - McGregor, A. M.

PY - 1995/6

Y1 - 1995/6

N2 - The effects of pindolol pretreatment (2 days) on prolactin and cortisol responses to a single dose of (+)-fenfluramine (30 mg po) were examined in nine healthy male volunteers. Pindolol pretreatment attenuated the (+)-fenfluramine-induced increase in prolactin concentrations but failed to affect the (+)-fenfluramine-induced cortisol increase. These data provide evidence in support of 5-HT1A receptor involvement in the regulation of prolactin secretion but question its importance in the regulation of cortisol secretion in man

AB - The effects of pindolol pretreatment (2 days) on prolactin and cortisol responses to a single dose of (+)-fenfluramine (30 mg po) were examined in nine healthy male volunteers. Pindolol pretreatment attenuated the (+)-fenfluramine-induced increase in prolactin concentrations but failed to affect the (+)-fenfluramine-induced cortisol increase. These data provide evidence in support of 5-HT1A receptor involvement in the regulation of prolactin secretion but question its importance in the regulation of cortisol secretion in man

KW - 5-HT receptors

KW - Cortisol

KW - Fenfluramine

KW - Man

KW - Pindolol

KW - Prolactin

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EP - 314

JO - Psychopharmacology

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ER -

Evidence for 5-hydroxytryptamine_1A receptor involvement in the control of prolactin secretion in man

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Keywords

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