Evidence for 5-hydroxytryptamine1A receptor involvement in the control of prolactin secretion in man

E. Palazidou, J. Stephenson, J. Butler, P. Coskeran, S. Chambers, A. M. McGregor

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

The effects of pindolol pretreatment (2 days) on prolactin and cortisol responses to a single dose of (+)-fenfluramine (30 mg po) were examined in nine healthy male volunteers. Pindolol pretreatment attenuated the (+)-fenfluramine-induced increase in prolactin concentrations but failed to affect the (+)-fenfluramine-induced cortisol increase. These data provide evidence in support of 5-HT1A receptor involvement in the regulation of prolactin secretion but question its importance in the regulation of cortisol secretion in man

Original languageEnglish
Pages (from-to)311-314
Number of pages4
JournalPsychopharmacology
Volume119
Issue number3
DOIs
Publication statusPublished - Jun 1995

Keywords

  • 5-HT receptors
  • Cortisol
  • Fenfluramine
  • Man
  • Pindolol
  • Prolactin

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