Evidence for 5-hydroxytryptamine1A receptor involvement in the control of prolactin secretion in man

E. Palazidou; J. Stephenson; J. Butler; P. Coskeran; S. Chambers; A. M. McGregor

doi:10.1007/BF02246297

Evidence for 5-hydroxytryptamine_1A receptor involvement in the control of prolactin secretion in man

E. Palazidou
, J. Stephenson
, J. Butler
, P. Coskeran
, S. Chambers
, A. M. McGregor

Medical School

King's College London

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of pindolol pretreatment (2 days) on prolactin and cortisol responses to a single dose of (+)-fenfluramine (30 mg po) were examined in nine healthy male volunteers. Pindolol pretreatment attenuated the (+)-fenfluramine-induced increase in prolactin concentrations but failed to affect the (+)-fenfluramine-induced cortisol increase. These data provide evidence in support of 5-HT1A receptor involvement in the regulation of prolactin secretion but question its importance in the regulation of cortisol secretion in man

Original language	English
Pages (from-to)	311-314
Number of pages	4
Journal	Psychopharmacology
Volume	119
Issue number	3
DOIs	https://doi.org/10.1007/BF02246297
Publication status	Published - Jun 1995

Keywords

5-HT receptors
Cortisol
Fenfluramine
Man
Pindolol
Prolactin

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10.1007/BF02246297

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title = "Evidence for 5-hydroxytryptamine1A receptor involvement in the control of prolactin secretion in man",

abstract = "The effects of pindolol pretreatment (2 days) on prolactin and cortisol responses to a single dose of (+)-fenfluramine (30 mg po) were examined in nine healthy male volunteers. Pindolol pretreatment attenuated the (+)-fenfluramine-induced increase in prolactin concentrations but failed to affect the (+)-fenfluramine-induced cortisol increase. These data provide evidence in support of 5-HT1A receptor involvement in the regulation of prolactin secretion but question its importance in the regulation of cortisol secretion in man",

keywords = "5-HT receptors, Cortisol, Fenfluramine, Man, Pindolol, Prolactin",

author = "E. Palazidou and J. Stephenson and J. Butler and P. Coskeran and S. Chambers and McGregor, \{A. M.\}",

year = "1995",

month = jun,

doi = "10.1007/BF02246297",

language = "English",

volume = "119",

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journal = "Psychopharmacology",

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T1 - Evidence for 5-hydroxytryptamine1A receptor involvement in the control of prolactin secretion in man

AU - Palazidou, E.

AU - Stephenson, J.

AU - Butler, J.

AU - Coskeran, P.

AU - Chambers, S.

AU - McGregor, A. M.

PY - 1995/6

Y1 - 1995/6

N2 - The effects of pindolol pretreatment (2 days) on prolactin and cortisol responses to a single dose of (+)-fenfluramine (30 mg po) were examined in nine healthy male volunteers. Pindolol pretreatment attenuated the (+)-fenfluramine-induced increase in prolactin concentrations but failed to affect the (+)-fenfluramine-induced cortisol increase. These data provide evidence in support of 5-HT1A receptor involvement in the regulation of prolactin secretion but question its importance in the regulation of cortisol secretion in man

AB - The effects of pindolol pretreatment (2 days) on prolactin and cortisol responses to a single dose of (+)-fenfluramine (30 mg po) were examined in nine healthy male volunteers. Pindolol pretreatment attenuated the (+)-fenfluramine-induced increase in prolactin concentrations but failed to affect the (+)-fenfluramine-induced cortisol increase. These data provide evidence in support of 5-HT1A receptor involvement in the regulation of prolactin secretion but question its importance in the regulation of cortisol secretion in man

KW - 5-HT receptors

KW - Cortisol

KW - Fenfluramine

KW - Man

KW - Pindolol

KW - Prolactin

UR - https://www.scopus.com/pages/publications/0028989235

U2 - 10.1007/BF02246297

DO - 10.1007/BF02246297

M3 - Article

C2 - 7675967

AN - SCOPUS:0028989235

SN - 0033-3158

VL - 119

SP - 311

EP - 314

JO - Psychopharmacology

JF - Psychopharmacology

IS - 3

ER -

Evidence for 5-hydroxytryptamine_1A receptor involvement in the control of prolactin secretion in man

Abstract

Keywords

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