Étude expérimentale de la phase précoce decicatrisation tendineuse: un gel plasmatique enrichi en plaquettes influence-t-il l'expression de l'IGF1?

Translated title of the contribution: Experimental study of tendon healing early phase: Is IGF-1 expression influenced by platelet rich plasma gel?

D. N. Lyras, K. Kazakos, G. Agrogiannis, D. Verettas, A. Kokka, G. Kiziridis, E. Chronopoulos, M. Tryfonidis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: It is well established that growth factors play a critical role in the healing process of connective tissues. To our knowledge, there are no studies in literature concerning the influence of platelet rich plasma (PRP) on growth factors expression. Hypothesis: The aim of this study was to assess the effect of a single application of PRP gel in a patellar tendon defect on the spatial and temporal expression of Insulin-like Growth Factor 1 (IGF-1) during tendon healing. Materials and methods: Twenty-four animals were randomized to receive PRP (PRPFast, Bioteck) in a gel form (PRP group) and 24 to serve as untreated controls (Control group). A defect of 3 mm × 10 mm was surgically created on the tendon under general anaesthetic and in the PRP group, PRP gel was applied to fill the tendon defect whereas no treatment was applied in the control group. Six animals (12 limbs) from each treatment group were sacrificed after one, two, three and four weeks following treatment. Histological and immunohistochemical staining were performed.

Translated title of the contributionExperimental study of tendon healing early phase: Is IGF-1 expression influenced by platelet rich plasma gel?
Original languageFrench
Pages (from-to)451-452
Number of pages2
JournalRevue de Chirurgie Orthopedique et Traumatologique
Volume96
Issue number4
DOIs
Publication statusPublished - Jun 2010

Keywords

  • Growth factors
  • IGF-1
  • Immunohistochemistry
  • PRP
  • Tendon healing

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