Fetal cystic hygromata: Insights gained from fetal blood sampling

Yuen Tannirandorn, Umberto Nicolini, Peter C. Nicolaidis, Nicholas M. Fisk, Sabaratnam Arulkumaran, Charles H. Rodeck

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Twelve second‐trimester fetuses with cystic hygroma underwent fetal blood sampling for rapid karyotyping, haematologic evaluation, and blood gas analysis. An abnormal karyotype was found in seven cases: monosomy X in five, trisomy 21 in one, and trisomy 13 in the other. Eight often fetuses undergoing blood gas analysis showed hypoxaemia, five of which were growth‐retarded. Nine pregnancies were terminated. Of the remaining three, only one fetus survived the perinatal period.

Original languageEnglish
Pages (from-to)189-193
Number of pages5
JournalPrenatal Diagnosis
Issue number3
Publication statusPublished - 1990


  • Cystic hygroma
  • Fetal blood sampling
  • Prenatal diagnosis


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