Fibrosing cholestatic hepatitis in a renal transplant recipient associated with the hepatitis B virus precore mutant

Jonathan C L Booth, Rob D. Goldin, Jonathan L. Brown, Peter Karayiannis, Howard C. Thomas

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

A patient with evidence of chronic infection with hepatitis B virus (seropositive for hepatitis B surface antigen, and with antibody to hepatitis B e antigen) underwent renal transplantation, which subsequently failed. The patient developed abnormal liver function tests and 8 months after the removal of the transplanted kidney, hepatitis B virus DNA was detected in the serum in the absence of hepatitis B e antigen. Liver biopsy revealed the presence of fibrosing cholestatic hepatitis. Sequence analysis of the serum hepatitis B virus DNA showed the presence of the pre-core mutant. This case shows that fibrosing cholestatic hepatitis can occur outside the setting liver transplantation, and coincided with the development of the pre-core mutant of hepatitis B virus.

Original languageEnglish
Pages (from-to)500-503
Number of pages4
JournalJournal of Hepatology
Volume22
Issue number4
DOIs
Publication statusPublished - 1995

Keywords

  • Immusuppression
  • Polymerase chain reaction
  • Pre-core mutant

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