Abstract
A patient with evidence of chronic infection with hepatitis B virus (seropositive for hepatitis B surface antigen, and with antibody to hepatitis B e antigen) underwent renal transplantation, which subsequently failed. The patient developed abnormal liver function tests and 8 months after the removal of the transplanted kidney, hepatitis B virus DNA was detected in the serum in the absence of hepatitis B e antigen. Liver biopsy revealed the presence of fibrosing cholestatic hepatitis. Sequence analysis of the serum hepatitis B virus DNA showed the presence of the pre-core mutant. This case shows that fibrosing cholestatic hepatitis can occur outside the setting liver transplantation, and coincided with the development of the pre-core mutant of hepatitis B virus.
Original language | English |
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Pages (from-to) | 500-503 |
Number of pages | 4 |
Journal | Journal of Hepatology |
Volume | 22 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1995 |
Keywords
- Immusuppression
- Polymerase chain reaction
- Pre-core mutant