Fibrosing cholestatic hepatitis in a renal transplant recipient associated with the hepatitis B virus precore mutant

Jonathan C L Booth; Rob D. Goldin; Jonathan L. Brown; Peter Karayiannis; Howard C. Thomas

doi:10.1016/0168-8278(95)80116-2

Fibrosing cholestatic hepatitis in a renal transplant recipient associated with the hepatitis B virus precore mutant

Jonathan C L Booth
, Rob D. Goldin
, Jonathan L. Brown
, Peter Karayiannis
, Howard C. Thomas

Medical School

Imperial College London

Research output: Contribution to journal › Article › peer-review

Abstract

A patient with evidence of chronic infection with hepatitis B virus (seropositive for hepatitis B surface antigen, and with antibody to hepatitis B e antigen) underwent renal transplantation, which subsequently failed. The patient developed abnormal liver function tests and 8 months after the removal of the transplanted kidney, hepatitis B virus DNA was detected in the serum in the absence of hepatitis B e antigen. Liver biopsy revealed the presence of fibrosing cholestatic hepatitis. Sequence analysis of the serum hepatitis B virus DNA showed the presence of the pre-core mutant. This case shows that fibrosing cholestatic hepatitis can occur outside the setting liver transplantation, and coincided with the development of the pre-core mutant of hepatitis B virus.

Original language	English
Pages (from-to)	500-503
Number of pages	4
Journal	Journal of Hepatology
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/0168-8278(95)80116-2
Publication status	Published - 1995

Keywords

Immusuppression
Polymerase chain reaction
Pre-core mutant

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0168-8278(95)80116-2

Cite this

@article{9fd05a503d62492898b1f3174c145ddd,

title = "Fibrosing cholestatic hepatitis in a renal transplant recipient associated with the hepatitis B virus precore mutant",

abstract = "A patient with evidence of chronic infection with hepatitis B virus (seropositive for hepatitis B surface antigen, and with antibody to hepatitis B e antigen) underwent renal transplantation, which subsequently failed. The patient developed abnormal liver function tests and 8 months after the removal of the transplanted kidney, hepatitis B virus DNA was detected in the serum in the absence of hepatitis B e antigen. Liver biopsy revealed the presence of fibrosing cholestatic hepatitis. Sequence analysis of the serum hepatitis B virus DNA showed the presence of the pre-core mutant. This case shows that fibrosing cholestatic hepatitis can occur outside the setting liver transplantation, and coincided with the development of the pre-core mutant of hepatitis B virus.",

keywords = "Immusuppression, Polymerase chain reaction, Pre-core mutant",

author = "Booth, \{Jonathan C L\} and Goldin, \{Rob D.\} and Brown, \{Jonathan L.\} and Peter Karayiannis and Thomas, \{Howard C.\}",

year = "1995",

doi = "10.1016/0168-8278(95)80116-2",

language = "English",

volume = "22",

pages = "500--503",

journal = "Journal of Hepatology",

issn = "0168-8278",

publisher = "Elsevier B.V.",

number = "4",

}

TY - JOUR

T1 - Fibrosing cholestatic hepatitis in a renal transplant recipient associated with the hepatitis B virus precore mutant

AU - Booth, Jonathan C L

AU - Goldin, Rob D.

AU - Brown, Jonathan L.

AU - Karayiannis, Peter

AU - Thomas, Howard C.

PY - 1995

Y1 - 1995

N2 - A patient with evidence of chronic infection with hepatitis B virus (seropositive for hepatitis B surface antigen, and with antibody to hepatitis B e antigen) underwent renal transplantation, which subsequently failed. The patient developed abnormal liver function tests and 8 months after the removal of the transplanted kidney, hepatitis B virus DNA was detected in the serum in the absence of hepatitis B e antigen. Liver biopsy revealed the presence of fibrosing cholestatic hepatitis. Sequence analysis of the serum hepatitis B virus DNA showed the presence of the pre-core mutant. This case shows that fibrosing cholestatic hepatitis can occur outside the setting liver transplantation, and coincided with the development of the pre-core mutant of hepatitis B virus.

AB - A patient with evidence of chronic infection with hepatitis B virus (seropositive for hepatitis B surface antigen, and with antibody to hepatitis B e antigen) underwent renal transplantation, which subsequently failed. The patient developed abnormal liver function tests and 8 months after the removal of the transplanted kidney, hepatitis B virus DNA was detected in the serum in the absence of hepatitis B e antigen. Liver biopsy revealed the presence of fibrosing cholestatic hepatitis. Sequence analysis of the serum hepatitis B virus DNA showed the presence of the pre-core mutant. This case shows that fibrosing cholestatic hepatitis can occur outside the setting liver transplantation, and coincided with the development of the pre-core mutant of hepatitis B virus.

KW - Immusuppression

KW - Polymerase chain reaction

KW - Pre-core mutant

UR - https://www.scopus.com/pages/publications/0028960909

U2 - 10.1016/0168-8278(95)80116-2

DO - 10.1016/0168-8278(95)80116-2

M3 - Article

C2 - 7665870

AN - SCOPUS:0028960909

SN - 0168-8278

VL - 22

SP - 500

EP - 503

JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 4

ER -

Fibrosing cholestatic hepatitis in a renal transplant recipient associated with the hepatitis B virus precore mutant

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this