TY - JOUR
T1 - Food protein induced proctocolitis
T2 - A benign condition with an obscure immunologic mechanism
AU - Tsabouri, Sophia
AU - Nicolaou, Nicolaos
AU - Douros, Konstantinos
AU - Papadopoulou, Athina
AU - Priftis, Kostas N.
PY - 2017
Y1 - 2017
N2 - Food protein-induced proctocolitis (FPIP) is the most common colonic manifestation of food allergy in infants, accounting for up to 60% of exclusively breast-fed children. The causative foods derived from the mother’s diet, which are then excreted in her milk. The suggested risk factors for the development of FPIP are an immature immune system, altered intestinal permeability and other factors that activate local immune function, such as genetic susceptibility in combination with particularly sensitizing foods. FPIP is an enhanced immune responsiveness of some infants to very small amounts of food antigens, inducing an inflammatory mucosal response, mediated by T cells.
AB - Food protein-induced proctocolitis (FPIP) is the most common colonic manifestation of food allergy in infants, accounting for up to 60% of exclusively breast-fed children. The causative foods derived from the mother’s diet, which are then excreted in her milk. The suggested risk factors for the development of FPIP are an immature immune system, altered intestinal permeability and other factors that activate local immune function, such as genetic susceptibility in combination with particularly sensitizing foods. FPIP is an enhanced immune responsiveness of some infants to very small amounts of food antigens, inducing an inflammatory mucosal response, mediated by T cells.
KW - Allergic proctocolitis
KW - Breast feeding
KW - Food allergy
KW - Immunologic response
KW - Infants
KW - Intolerance
UR - http://www.scopus.com/inward/record.url?scp=85025084929&partnerID=8YFLogxK
U2 - 10.2174/1871530316666170331165356
DO - 10.2174/1871530316666170331165356
M3 - Review article
AN - SCOPUS:85025084929
SN - 1871-5303
VL - 17
SP - 32
EP - 37
JO - Endocrine, Metabolic and Immune Disorders - Drug Targets
JF - Endocrine, Metabolic and Immune Disorders - Drug Targets
IS - 1
ER -