Food protein induced proctocolitis: A benign condition with an obscure immunologic mechanism

Sophia Tsabouri; Nicolaos Nicolaou; Konstantinos Douros; Athina Papadopoulou; Kostas N. Priftis

doi:10.2174/1871530316666170331165356

Food protein induced proctocolitis: A benign condition with an obscure immunologic mechanism

Sophia Tsabouri
, Nicolaos Nicolaou
, Konstantinos Douros
, Athina Papadopoulou
, Kostas N. Priftis

Medical School

Research output: Contribution to journal › Review article › peer-review

Abstract

Food protein-induced proctocolitis (FPIP) is the most common colonic manifestation of food allergy in infants, accounting for up to 60% of exclusively breast-fed children. The causative foods derived from the mother’s diet, which are then excreted in her milk. The suggested risk factors for the development of FPIP are an immature immune system, altered intestinal permeability and other factors that activate local immune function, such as genetic susceptibility in combination with particularly sensitizing foods. FPIP is an enhanced immune responsiveness of some infants to very small amounts of food antigens, inducing an inflammatory mucosal response, mediated by T cells.

Original language	English
Pages (from-to)	32-37
Number of pages	6
Journal	Endocrine, Metabolic and Immune Disorders - Drug Targets
Volume	17
Issue number	1
DOIs	https://doi.org/10.2174/1871530316666170331165356
Publication status	Published - 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Allergic proctocolitis
Breast feeding
Food allergy
Immunologic response
Infants
Intolerance

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10.2174/1871530316666170331165356

Cite this

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title = "Food protein induced proctocolitis: A benign condition with an obscure immunologic mechanism",

abstract = "Food protein-induced proctocolitis (FPIP) is the most common colonic manifestation of food allergy in infants, accounting for up to 60\% of exclusively breast-fed children. The causative foods derived from the mother{\textquoteright}s diet, which are then excreted in her milk. The suggested risk factors for the development of FPIP are an immature immune system, altered intestinal permeability and other factors that activate local immune function, such as genetic susceptibility in combination with particularly sensitizing foods. FPIP is an enhanced immune responsiveness of some infants to very small amounts of food antigens, inducing an inflammatory mucosal response, mediated by T cells.",

keywords = "Allergic proctocolitis, Breast feeding, Food allergy, Immunologic response, Infants, Intolerance",

author = "Sophia Tsabouri and Nicolaos Nicolaou and Konstantinos Douros and Athina Papadopoulou and Priftis, \{Kostas N.\}",

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doi = "10.2174/1871530316666170331165356",

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T1 - Food protein induced proctocolitis

T2 - A benign condition with an obscure immunologic mechanism

AU - Tsabouri, Sophia

AU - Nicolaou, Nicolaos

AU - Douros, Konstantinos

AU - Papadopoulou, Athina

AU - Priftis, Kostas N.

PY - 2017

Y1 - 2017

N2 - Food protein-induced proctocolitis (FPIP) is the most common colonic manifestation of food allergy in infants, accounting for up to 60% of exclusively breast-fed children. The causative foods derived from the mother’s diet, which are then excreted in her milk. The suggested risk factors for the development of FPIP are an immature immune system, altered intestinal permeability and other factors that activate local immune function, such as genetic susceptibility in combination with particularly sensitizing foods. FPIP is an enhanced immune responsiveness of some infants to very small amounts of food antigens, inducing an inflammatory mucosal response, mediated by T cells.

AB - Food protein-induced proctocolitis (FPIP) is the most common colonic manifestation of food allergy in infants, accounting for up to 60% of exclusively breast-fed children. The causative foods derived from the mother’s diet, which are then excreted in her milk. The suggested risk factors for the development of FPIP are an immature immune system, altered intestinal permeability and other factors that activate local immune function, such as genetic susceptibility in combination with particularly sensitizing foods. FPIP is an enhanced immune responsiveness of some infants to very small amounts of food antigens, inducing an inflammatory mucosal response, mediated by T cells.

KW - Allergic proctocolitis

KW - Breast feeding

KW - Food allergy

KW - Immunologic response

KW - Infants

KW - Intolerance

UR - https://www.scopus.com/pages/publications/85025084929

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DO - 10.2174/1871530316666170331165356

M3 - Review article

AN - SCOPUS:85025084929

SN - 1871-5303

VL - 17

SP - 32

EP - 37

JO - Endocrine, Metabolic and Immune Disorders - Drug Targets

JF - Endocrine, Metabolic and Immune Disorders - Drug Targets

IS - 1

ER -

Food protein induced proctocolitis: A benign condition with an obscure immunologic mechanism

Abstract

UN SDGs

Keywords

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