G-protein-coupled receptors in vascular smooth muscle cells

Research output: Contribution to journalArticlepeer-review


Vasoactive peptides like thrombin, angiotensin II and endothelin induce vascular smooth muscle cell (VSMC) contraction via activation of G-protein-coupled receptors. Recent studies have shown that they also induce VSMC migration and proliferation, processes which are important in the remodelling of the vasculature during embryogenesis and in the response to vascular injury. G-protein-coupled receptor-mediated mitogenic signals appear to be transmitted via a number of intracellular mechanisms which include proto-oncogene gene expression, G-protein-mediated protein translocation and tyrosine phosphorylation of growth factor receptor proteins, and activation of autocrine growth factor pathways. The ability of vasoactive peptides to have an impact on signalling cascades mediated by growth factor tyrosine kinase receptors may be important in the pathogenesis of diseases in the vasculature.

Original languageEnglish
Pages (from-to)90-97
Number of pages8
Issue number2
Publication statusPublished - 14 May 1998


  • G proteins
  • Proliferation
  • Vascular smooth muscle
  • Vasoactive peptide receptors


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