Genetic and environmental factors contributing to parkinson’s disease: A case-control study in the cypriot population

Andrea Georgiou, Christiana A. Demetriou, Yiolanda P. Christou, Alexandros Heraclides, Eleni Leonidou, Panayiotis Loukaides, Elena Yiasoumi, Marios Pantziaris, Kleopas A. Kleopa, Savvas S. Papacostas, Maria A. Loizidou, Andreas Hadjisavvas, Eleni Zamba-Papanicolaou

    Research output: Contribution to journalArticle

    Abstract

    Introduction: Parkinson’s disease (PD) is a neurodegenerative disorder affecting a substantial proportion of the elderly Cypriot population. The objective of this study was to evaluate PD risk variants that have been identified previously in Genome Wide Association Studies (GWAS) and to find environmental factors that are predictors for PD onset in the Cypriot population. Methods: A case-control study was conducted with a total of 235 PD patients and 464 healthy controls of Greek-Cypriot ethnicity. Demographic and lifestyle characteristics, exposure to PD risk factors and clinical data were collected. Moreover, 13 previously GWAS-identified PD risk variants were genotyped. Univariate and multivariate regression analyses examined the association between a number of environmental and genetic factors and PD. Results: Multivariable regression analysis revealed that exposure to both pesticides and other toxic substances (P = 0.03), severe head injury accompanied with fainting (P = 0.001), nuts consumption (P = 0.004), red meat consumption (P = 0.02), and soft drinks consumption (P = 0.008) were increasing the risk for PD, whereas cumulative smoking (P = 0.02), and fish consumption (P = 0.02) were decreasing the risk for PD. Five out of the 13 tested SNPs (rs12185268, rs6599389, rs356220, rs13312, and rs17649553) were confirmed to be nominally significantly associated (P < 0.05) with PD risk in the Cypriot population. Conclusions: Collectively, this case-control study has shed some light on the nature of PD epidemiology in Cyprus, by demonstrating a number of genetic and environmental determinants of PD in the Cypriot population.

    Original languageEnglish
    Article number1047
    JournalFrontiers in Neurology
    Volume10
    Issue numberOCT
    DOIs
    Publication statusPublished - 1 Jan 2019

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    Parkinson Disease
    Case-Control Studies
    Population
    Genome-Wide Association Study
    Regression Analysis
    Cyprus
    Carbonated Beverages
    Inborn Genetic Diseases
    Nuts
    Poisons
    Syncope
    Substance P
    Craniocerebral Trauma
    Pesticides
    Neurodegenerative Diseases
    Single Nucleotide Polymorphism
    Life Style
    Fishes
    Epidemiology
    Multivariate Analysis

    Keywords

    • Case-control study
    • Cypriot population
    • Environmental factors
    • Epidemiology
    • Genetic variants
    • Observational study
    • Parkinson’s disease

    Cite this

    Georgiou, Andrea ; Demetriou, Christiana A. ; Christou, Yiolanda P. ; Heraclides, Alexandros ; Leonidou, Eleni ; Loukaides, Panayiotis ; Yiasoumi, Elena ; Pantziaris, Marios ; Kleopa, Kleopas A. ; Papacostas, Savvas S. ; Loizidou, Maria A. ; Hadjisavvas, Andreas ; Zamba-Papanicolaou, Eleni. / Genetic and environmental factors contributing to parkinson’s disease : A case-control study in the cypriot population. In: Frontiers in Neurology. 2019 ; Vol. 10, No. OCT.
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    title = "Genetic and environmental factors contributing to parkinson’s disease: A case-control study in the cypriot population",
    abstract = "Introduction: Parkinson’s disease (PD) is a neurodegenerative disorder affecting a substantial proportion of the elderly Cypriot population. The objective of this study was to evaluate PD risk variants that have been identified previously in Genome Wide Association Studies (GWAS) and to find environmental factors that are predictors for PD onset in the Cypriot population. Methods: A case-control study was conducted with a total of 235 PD patients and 464 healthy controls of Greek-Cypriot ethnicity. Demographic and lifestyle characteristics, exposure to PD risk factors and clinical data were collected. Moreover, 13 previously GWAS-identified PD risk variants were genotyped. Univariate and multivariate regression analyses examined the association between a number of environmental and genetic factors and PD. Results: Multivariable regression analysis revealed that exposure to both pesticides and other toxic substances (P = 0.03), severe head injury accompanied with fainting (P = 0.001), nuts consumption (P = 0.004), red meat consumption (P = 0.02), and soft drinks consumption (P = 0.008) were increasing the risk for PD, whereas cumulative smoking (P = 0.02), and fish consumption (P = 0.02) were decreasing the risk for PD. Five out of the 13 tested SNPs (rs12185268, rs6599389, rs356220, rs13312, and rs17649553) were confirmed to be nominally significantly associated (P < 0.05) with PD risk in the Cypriot population. Conclusions: Collectively, this case-control study has shed some light on the nature of PD epidemiology in Cyprus, by demonstrating a number of genetic and environmental determinants of PD in the Cypriot population.",
    keywords = "Case-control study, Cypriot population, Environmental factors, Epidemiology, Genetic variants, Observational study, Parkinson’s disease",
    author = "Andrea Georgiou and Demetriou, {Christiana A.} and Christou, {Yiolanda P.} and Alexandros Heraclides and Eleni Leonidou and Panayiotis Loukaides and Elena Yiasoumi and Marios Pantziaris and Kleopa, {Kleopas A.} and Papacostas, {Savvas S.} and Loizidou, {Maria A.} and Andreas Hadjisavvas and Eleni Zamba-Papanicolaou",
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    Georgiou, A, Demetriou, CA, Christou, YP, Heraclides, A, Leonidou, E, Loukaides, P, Yiasoumi, E, Pantziaris, M, Kleopa, KA, Papacostas, SS, Loizidou, MA, Hadjisavvas, A & Zamba-Papanicolaou, E 2019, 'Genetic and environmental factors contributing to parkinson’s disease: A case-control study in the cypriot population', Frontiers in Neurology, vol. 10, no. OCT, 1047. https://doi.org/10.3389/fneur.2019.01047

    Genetic and environmental factors contributing to parkinson’s disease : A case-control study in the cypriot population. / Georgiou, Andrea; Demetriou, Christiana A.; Christou, Yiolanda P.; Heraclides, Alexandros; Leonidou, Eleni; Loukaides, Panayiotis; Yiasoumi, Elena; Pantziaris, Marios; Kleopa, Kleopas A.; Papacostas, Savvas S.; Loizidou, Maria A.; Hadjisavvas, Andreas; Zamba-Papanicolaou, Eleni.

    In: Frontiers in Neurology, Vol. 10, No. OCT, 1047, 01.01.2019.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Genetic and environmental factors contributing to parkinson’s disease

    T2 - A case-control study in the cypriot population

    AU - Georgiou, Andrea

    AU - Demetriou, Christiana A.

    AU - Christou, Yiolanda P.

    AU - Heraclides, Alexandros

    AU - Leonidou, Eleni

    AU - Loukaides, Panayiotis

    AU - Yiasoumi, Elena

    AU - Pantziaris, Marios

    AU - Kleopa, Kleopas A.

    AU - Papacostas, Savvas S.

    AU - Loizidou, Maria A.

    AU - Hadjisavvas, Andreas

    AU - Zamba-Papanicolaou, Eleni

    PY - 2019/1/1

    Y1 - 2019/1/1

    N2 - Introduction: Parkinson’s disease (PD) is a neurodegenerative disorder affecting a substantial proportion of the elderly Cypriot population. The objective of this study was to evaluate PD risk variants that have been identified previously in Genome Wide Association Studies (GWAS) and to find environmental factors that are predictors for PD onset in the Cypriot population. Methods: A case-control study was conducted with a total of 235 PD patients and 464 healthy controls of Greek-Cypriot ethnicity. Demographic and lifestyle characteristics, exposure to PD risk factors and clinical data were collected. Moreover, 13 previously GWAS-identified PD risk variants were genotyped. Univariate and multivariate regression analyses examined the association between a number of environmental and genetic factors and PD. Results: Multivariable regression analysis revealed that exposure to both pesticides and other toxic substances (P = 0.03), severe head injury accompanied with fainting (P = 0.001), nuts consumption (P = 0.004), red meat consumption (P = 0.02), and soft drinks consumption (P = 0.008) were increasing the risk for PD, whereas cumulative smoking (P = 0.02), and fish consumption (P = 0.02) were decreasing the risk for PD. Five out of the 13 tested SNPs (rs12185268, rs6599389, rs356220, rs13312, and rs17649553) were confirmed to be nominally significantly associated (P < 0.05) with PD risk in the Cypriot population. Conclusions: Collectively, this case-control study has shed some light on the nature of PD epidemiology in Cyprus, by demonstrating a number of genetic and environmental determinants of PD in the Cypriot population.

    AB - Introduction: Parkinson’s disease (PD) is a neurodegenerative disorder affecting a substantial proportion of the elderly Cypriot population. The objective of this study was to evaluate PD risk variants that have been identified previously in Genome Wide Association Studies (GWAS) and to find environmental factors that are predictors for PD onset in the Cypriot population. Methods: A case-control study was conducted with a total of 235 PD patients and 464 healthy controls of Greek-Cypriot ethnicity. Demographic and lifestyle characteristics, exposure to PD risk factors and clinical data were collected. Moreover, 13 previously GWAS-identified PD risk variants were genotyped. Univariate and multivariate regression analyses examined the association between a number of environmental and genetic factors and PD. Results: Multivariable regression analysis revealed that exposure to both pesticides and other toxic substances (P = 0.03), severe head injury accompanied with fainting (P = 0.001), nuts consumption (P = 0.004), red meat consumption (P = 0.02), and soft drinks consumption (P = 0.008) were increasing the risk for PD, whereas cumulative smoking (P = 0.02), and fish consumption (P = 0.02) were decreasing the risk for PD. Five out of the 13 tested SNPs (rs12185268, rs6599389, rs356220, rs13312, and rs17649553) were confirmed to be nominally significantly associated (P < 0.05) with PD risk in the Cypriot population. Conclusions: Collectively, this case-control study has shed some light on the nature of PD epidemiology in Cyprus, by demonstrating a number of genetic and environmental determinants of PD in the Cypriot population.

    KW - Case-control study

    KW - Cypriot population

    KW - Environmental factors

    KW - Epidemiology

    KW - Genetic variants

    KW - Observational study

    KW - Parkinson’s disease

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    U2 - 10.3389/fneur.2019.01047

    DO - 10.3389/fneur.2019.01047

    M3 - Article

    AN - SCOPUS:85074478073

    VL - 10

    JO - Frontiers in Neurology

    JF - Frontiers in Neurology

    SN - 1664-2295

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