Genetic polymorphisms in the DNA repair genes XRCC1, XRCC2 and XRCC3 and risk of breast cancer in Cyprus

Maria A. Loizidou, Thalia Michael, Susan L. Neuhausen, Robert F. Newbold, Yiola Marcou, Eleni Kakouri, Maria Daniel, Panayiotis Papadopoulos, Simos Malas, Kyriacos Kyriacou, Andreas Hadjisavvas

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)

Abstract

Population-based studies have reported significant associations between specific genetic polymorphisms and breast cancer susceptibility. A number of studies have demonstrated that common variants of genes involved in the DNA repair pathway act as low penetrance breast cancer susceptibility alleles. We aimed to investigate the association of single nucleotide polymorphisms (SNPs) in the DNA repair genes XRCC1, XRCC2 and XRCC3 and breast cancer in MASTOS, a population-based case-control study of 1,109 Cypriot women with breast cancer diagnosed between 40 and 70 years and 1,177 age-matched healthy controls. Five coding SNPs were genotyped including rs1799782, rs25489 and rs25487 in XRCC1, rs3218536 in XRCC2 and rs861539 in XRCC3. Homozygous XRCC1 280His carriers had an increased risk of breast cancer (odds ratio 4.68; 95% CI 1.01-21.7; P = 0.03). The XRCC2 188His allele was associated with a marginal protective effect for breast cancer (odds ratio 0.79; 95% CI 0.62-1.00; P = 0.05). No significant associations were observed between the other three SNPs and breast cancer. This study suggests that genetic variation in SNPs in XRCC1 and XRCC2 genes may influence breast cancer susceptibility.

Original languageEnglish
Pages (from-to)575-579
Number of pages5
JournalBreast Cancer Research and Treatment
Volume112
Issue number3
DOIs
Publication statusPublished - Dec 2008

Keywords

  • Breast cancer
  • Case-Control study
  • Cyprus
  • DNA repair
  • Genetic epidemiology
  • Polymorphisms
  • XRCC1
  • XRCC2
  • XRCC3

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